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Effects of Apple Pectin on Fecal Bacterial Enzymes in Azoxymethane‐induced Rat Colon Carcinogenesis

Because of the potential significance of colonic bacteria in colon carcinogenesis, we investigated the effect of pectin of different types on fecal bacterial enzymes (β‐glucuronidase, β‐glucosidase and tryptophanase) at various periods of time after feeding rats with pectin‐containing diets during a...

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Autores principales: Ohkami, Hideo, Tazawa, Kenji, Yamashita, Iwao, Shimizu, Tetsuro, Murai, Kenji, Kobashi, Kyoichi, Fujimaki, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920877/
https://www.ncbi.nlm.nih.gov/pubmed/7622415
http://dx.doi.org/10.1111/j.1349-7006.1995.tb02429.x
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author Ohkami, Hideo
Tazawa, Kenji
Yamashita, Iwao
Shimizu, Tetsuro
Murai, Kenji
Kobashi, Kyoichi
Fujimaki, Masao
author_facet Ohkami, Hideo
Tazawa, Kenji
Yamashita, Iwao
Shimizu, Tetsuro
Murai, Kenji
Kobashi, Kyoichi
Fujimaki, Masao
author_sort Ohkami, Hideo
collection PubMed
description Because of the potential significance of colonic bacteria in colon carcinogenesis, we investigated the effect of pectin of different types on fecal bacterial enzymes (β‐glucuronidase, β‐glucosidase and tryptophanase) at various periods of time after feeding rats with pectin‐containing diets during azoxymethane‐induced colon carcinogenesis. The diet supplemented with 20% apple pectin or 20% citrus pectin decreased the multiplicity of colon tumors, and the number of tumors was significantly decreased in the group fed apple pectin. The incidence of colon tumors in the apple pectin group was lower than that in the control group. The mean tumor size was similar among the three groups. Apple pectin feeding decreased fecal β‐glucosidase and tryptophanase levels. Furthermore, a significant decrease in the activity of β‐glucuronidase was observed in the apple pectin group during the initiation phase. These findings suggest that the protective effect of pectin on colon carcinogenesis may be dependent on the type of pectin and be related to the decrease of β‐glucuronidase activity in the initiation stage of carcinogenesis.
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spelling pubmed-59208772018-05-11 Effects of Apple Pectin on Fecal Bacterial Enzymes in Azoxymethane‐induced Rat Colon Carcinogenesis Ohkami, Hideo Tazawa, Kenji Yamashita, Iwao Shimizu, Tetsuro Murai, Kenji Kobashi, Kyoichi Fujimaki, Masao Jpn J Cancer Res Article Because of the potential significance of colonic bacteria in colon carcinogenesis, we investigated the effect of pectin of different types on fecal bacterial enzymes (β‐glucuronidase, β‐glucosidase and tryptophanase) at various periods of time after feeding rats with pectin‐containing diets during azoxymethane‐induced colon carcinogenesis. The diet supplemented with 20% apple pectin or 20% citrus pectin decreased the multiplicity of colon tumors, and the number of tumors was significantly decreased in the group fed apple pectin. The incidence of colon tumors in the apple pectin group was lower than that in the control group. The mean tumor size was similar among the three groups. Apple pectin feeding decreased fecal β‐glucosidase and tryptophanase levels. Furthermore, a significant decrease in the activity of β‐glucuronidase was observed in the apple pectin group during the initiation phase. These findings suggest that the protective effect of pectin on colon carcinogenesis may be dependent on the type of pectin and be related to the decrease of β‐glucuronidase activity in the initiation stage of carcinogenesis. Blackwell Publishing Ltd 1995-06 /pmc/articles/PMC5920877/ /pubmed/7622415 http://dx.doi.org/10.1111/j.1349-7006.1995.tb02429.x Text en
spellingShingle Article
Ohkami, Hideo
Tazawa, Kenji
Yamashita, Iwao
Shimizu, Tetsuro
Murai, Kenji
Kobashi, Kyoichi
Fujimaki, Masao
Effects of Apple Pectin on Fecal Bacterial Enzymes in Azoxymethane‐induced Rat Colon Carcinogenesis
title Effects of Apple Pectin on Fecal Bacterial Enzymes in Azoxymethane‐induced Rat Colon Carcinogenesis
title_full Effects of Apple Pectin on Fecal Bacterial Enzymes in Azoxymethane‐induced Rat Colon Carcinogenesis
title_fullStr Effects of Apple Pectin on Fecal Bacterial Enzymes in Azoxymethane‐induced Rat Colon Carcinogenesis
title_full_unstemmed Effects of Apple Pectin on Fecal Bacterial Enzymes in Azoxymethane‐induced Rat Colon Carcinogenesis
title_short Effects of Apple Pectin on Fecal Bacterial Enzymes in Azoxymethane‐induced Rat Colon Carcinogenesis
title_sort effects of apple pectin on fecal bacterial enzymes in azoxymethane‐induced rat colon carcinogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920877/
https://www.ncbi.nlm.nih.gov/pubmed/7622415
http://dx.doi.org/10.1111/j.1349-7006.1995.tb02429.x
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