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Inostamycin, an Inhibitor of P‐Glycoprotein Function, Interacts Specifically with Phosphatidylethanolamine

The mechanism of inostamycin action was further studied. When multidrug‐resistant KB‐C4 cells were preincubated with inostamycin for 30 min, the accumulation of [(3)H]vinblastine was increased for as long as 48 h thereafter. Inostamycin inhibited azidopine binding to P‐glycoprotein, even after KB pl...

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Detalles Bibliográficos
Autores principales: Kawada, Manabu, Umezawa, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920936/
https://www.ncbi.nlm.nih.gov/pubmed/7591966
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03099.x