Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70

The antitumor effects of high‐energy shock waves (HESW) in combination with ATX‐70 [a gallium‐porphyrin complex, 2,4‐bis(1‐decyloxyethyl)‐Ga(III)‐1,3,5,8‐tetramethylporphyrin‐6,7‐dipropionyi diaspartic acid] were investigated. In vitro, the cell damage to mouse MH134 hepatoma after HESW treatment wa...

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Detalles Bibliográficos
Autores principales: Maruyama, Michihiro, Asano, Takehide, Uematsu, Takeshi, Nakagohri, Toshio, Hasegawa, Masayuki, Miyauchi, Hideaki, Iwashita, Chikara, Isono, Kaichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1995
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920937/
https://www.ncbi.nlm.nih.gov/pubmed/7591955
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03088.x
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author Maruyama, Michihiro
Asano, Takehide
Uematsu, Takeshi
Nakagohri, Toshio
Hasegawa, Masayuki
Miyauchi, Hideaki
Iwashita, Chikara
Isono, Kaichi
author_facet Maruyama, Michihiro
Asano, Takehide
Uematsu, Takeshi
Nakagohri, Toshio
Hasegawa, Masayuki
Miyauchi, Hideaki
Iwashita, Chikara
Isono, Kaichi
author_sort Maruyama, Michihiro
collection PubMed
description The antitumor effects of high‐energy shock waves (HESW) in combination with ATX‐70 [a gallium‐porphyrin complex, 2,4‐bis(1‐decyloxyethyl)‐Ga(III)‐1,3,5,8‐tetramethylporphyrin‐6,7‐dipropionyi diaspartic acid] were investigated. In vitro, the cell damage to mouse MH134 hepatoma after HESW treatment was enhanced by adding ATX‐70. In vivo, HESW and ATX‐70 combination therapy inhibited cell growth. However, neither HESW treatment alone nor ATX‐70 treatment alone inhibited cell growth. These results imply that the antitumor effects of HESW and ATX‐70 combined therapy are caused by activation of ATX‐70 by HESW.
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spelling pubmed-59209372018-05-11 Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70 Maruyama, Michihiro Asano, Takehide Uematsu, Takeshi Nakagohri, Toshio Hasegawa, Masayuki Miyauchi, Hideaki Iwashita, Chikara Isono, Kaichi Jpn J Cancer Res Rapid Communication The antitumor effects of high‐energy shock waves (HESW) in combination with ATX‐70 [a gallium‐porphyrin complex, 2,4‐bis(1‐decyloxyethyl)‐Ga(III)‐1,3,5,8‐tetramethylporphyrin‐6,7‐dipropionyi diaspartic acid] were investigated. In vitro, the cell damage to mouse MH134 hepatoma after HESW treatment was enhanced by adding ATX‐70. In vivo, HESW and ATX‐70 combination therapy inhibited cell growth. However, neither HESW treatment alone nor ATX‐70 treatment alone inhibited cell growth. These results imply that the antitumor effects of HESW and ATX‐70 combined therapy are caused by activation of ATX‐70 by HESW. Blackwell Publishing Ltd 1995-09 /pmc/articles/PMC5920937/ /pubmed/7591955 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03088.x Text en
spellingShingle Rapid Communication
Maruyama, Michihiro
Asano, Takehide
Uematsu, Takeshi
Nakagohri, Toshio
Hasegawa, Masayuki
Miyauchi, Hideaki
Iwashita, Chikara
Isono, Kaichi
Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70
title Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70
title_full Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70
title_fullStr Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70
title_full_unstemmed Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70
title_short Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70
title_sort enhancement of the antitumor effect by combined use of high‐energy shock waves and atx‐70
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920937/
https://www.ncbi.nlm.nih.gov/pubmed/7591955
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03088.x
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