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Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells

mRNA levels for ten protein tyrosine phosphatases (PTPs), PTP‐S, PTPH1, PTP‐1, GLEPP1, LRP, PTP1D, PTPG1, PTPγ, PTPδ, and LAR, were determined during regeneration of rat liver, and mRNA levels for 5 PTPs, PTP‐S, PTP‐1, PTPγ, PTPδ, and LRP, were determined in three lines of rat ascites hepatoma cells...

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Detalles Bibliográficos
Autores principales: Kitamura, Takaya, Nakamura, Koji, Mizuno, Yusuke, Kikuchi, Kunimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920938/
https://www.ncbi.nlm.nih.gov/pubmed/7591957
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03090.x
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author Kitamura, Takaya
Nakamura, Koji
Mizuno, Yusuke
Kikuchi, Kunimi
author_facet Kitamura, Takaya
Nakamura, Koji
Mizuno, Yusuke
Kikuchi, Kunimi
author_sort Kitamura, Takaya
collection PubMed
description mRNA levels for ten protein tyrosine phosphatases (PTPs), PTP‐S, PTPH1, PTP‐1, GLEPP1, LRP, PTP1D, PTPG1, PTPγ, PTPδ, and LAR, were determined during regeneration of rat liver, and mRNA levels for 5 PTPs, PTP‐S, PTP‐1, PTPγ, PTPδ, and LRP, were determined in three lines of rat ascites hepatoma cells. In regenerating rat liver, the expression patterns of PTP genes after partial hepatectomy could be classified into four groups. In group 1 (PTP‐S and PTPH1), the mRNA levels increased rapidly, reached a maximum 7 h after partial hepatectomy, remained at a plateau for 1–2 days and then decreased gradually. In group 2 (PTP‐1, GLEPP1, and LRP), the mRNA levels showed two peaks on days 1 and 5, and then decreased gradually. In group 3 (PTP1D and PTPG1), the mRNA levels increased rapidly, reached a maximum at 7 h, remained high for several days, and then did not decrease but rather increased after day 7. In group 4 (PTPγ, PTPδ, and LAR), the mRNA levels remained constant for the first 5 days and increased over the control levels after day 7. In rat ascites hepatomas, gene expression of non‐receptor‐like PTPs (PTP‐S and PTP‐1) showed various neoplastic alterations, whereas mRNAs of receptor‐like PTPs (PTPγ, PTPdL, and LRP) were lost or drastically decreased.
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spelling pubmed-59209382018-05-11 Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells Kitamura, Takaya Nakamura, Koji Mizuno, Yusuke Kikuchi, Kunimi Jpn J Cancer Res Article mRNA levels for ten protein tyrosine phosphatases (PTPs), PTP‐S, PTPH1, PTP‐1, GLEPP1, LRP, PTP1D, PTPG1, PTPγ, PTPδ, and LAR, were determined during regeneration of rat liver, and mRNA levels for 5 PTPs, PTP‐S, PTP‐1, PTPγ, PTPδ, and LRP, were determined in three lines of rat ascites hepatoma cells. In regenerating rat liver, the expression patterns of PTP genes after partial hepatectomy could be classified into four groups. In group 1 (PTP‐S and PTPH1), the mRNA levels increased rapidly, reached a maximum 7 h after partial hepatectomy, remained at a plateau for 1–2 days and then decreased gradually. In group 2 (PTP‐1, GLEPP1, and LRP), the mRNA levels showed two peaks on days 1 and 5, and then decreased gradually. In group 3 (PTP1D and PTPG1), the mRNA levels increased rapidly, reached a maximum at 7 h, remained high for several days, and then did not decrease but rather increased after day 7. In group 4 (PTPγ, PTPδ, and LAR), the mRNA levels remained constant for the first 5 days and increased over the control levels after day 7. In rat ascites hepatomas, gene expression of non‐receptor‐like PTPs (PTP‐S and PTP‐1) showed various neoplastic alterations, whereas mRNAs of receptor‐like PTPs (PTPγ, PTPdL, and LRP) were lost or drastically decreased. Blackwell Publishing Ltd 1995-09 /pmc/articles/PMC5920938/ /pubmed/7591957 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03090.x Text en
spellingShingle Article
Kitamura, Takaya
Nakamura, Koji
Mizuno, Yusuke
Kikuchi, Kunimi
Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells
title Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells
title_full Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells
title_fullStr Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells
title_full_unstemmed Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells
title_short Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells
title_sort gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920938/
https://www.ncbi.nlm.nih.gov/pubmed/7591957
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03090.x
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