Multiple Primary Cancers with Microsatellite Instability: Report of a Case

We report here a patient who developed a variety of tumors both synchronously and metachronously over a 2‐year period. The involved organs were the uterus, ureter, and small and large intestines. The patient underwent open surgery 3 times and polypcctomies 6 times. Postoperative histopathologic anal...

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Autores principales: Ichikawa, Daisuke, Takahashi, Toshio, Hashimoto, Naoya, Hoshima, Masakazu, Kitamura, Kazuya, Yamane, Tetsuro, Yamaguchi, Toshiharu, Abe, Tatsuo, Inazawa, Johji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920989/
https://www.ncbi.nlm.nih.gov/pubmed/8609041
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00207.x
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author Ichikawa, Daisuke
Takahashi, Toshio
Hashimoto, Naoya
Hoshima, Masakazu
Kitamura, Kazuya
Yamane, Tetsuro
Yamaguchi, Toshiharu
Abe, Tatsuo
Inazawa, Johji
author_facet Ichikawa, Daisuke
Takahashi, Toshio
Hashimoto, Naoya
Hoshima, Masakazu
Kitamura, Kazuya
Yamane, Tetsuro
Yamaguchi, Toshiharu
Abe, Tatsuo
Inazawa, Johji
author_sort Ichikawa, Daisuke
collection PubMed
description We report here a patient who developed a variety of tumors both synchronously and metachronously over a 2‐year period. The involved organs were the uterus, ureter, and small and large intestines. The patient underwent open surgery 3 times and polypcctomies 6 times. Postoperative histopathologic analysis showed 2 adenomas and 8 carcinomas. Genetic analysis revealed microsatellite instabilities at the tested loci in all 10 tumors, indicating that replication errors played an essential role in the tumorigenesis. Early identification of microsatellite instability could be useful for predicting development of additional primary cancers.
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spelling pubmed-59209892018-05-11 Multiple Primary Cancers with Microsatellite Instability: Report of a Case Ichikawa, Daisuke Takahashi, Toshio Hashimoto, Naoya Hoshima, Masakazu Kitamura, Kazuya Yamane, Tetsuro Yamaguchi, Toshiharu Abe, Tatsuo Inazawa, Johji Jpn J Cancer Res Article We report here a patient who developed a variety of tumors both synchronously and metachronously over a 2‐year period. The involved organs were the uterus, ureter, and small and large intestines. The patient underwent open surgery 3 times and polypcctomies 6 times. Postoperative histopathologic analysis showed 2 adenomas and 8 carcinomas. Genetic analysis revealed microsatellite instabilities at the tested loci in all 10 tumors, indicating that replication errors played an essential role in the tumorigenesis. Early identification of microsatellite instability could be useful for predicting development of additional primary cancers. Blackwell Publishing Ltd 1996-01 /pmc/articles/PMC5920989/ /pubmed/8609041 http://dx.doi.org/10.1111/j.1349-7006.1996.tb00207.x Text en
spellingShingle Article
Ichikawa, Daisuke
Takahashi, Toshio
Hashimoto, Naoya
Hoshima, Masakazu
Kitamura, Kazuya
Yamane, Tetsuro
Yamaguchi, Toshiharu
Abe, Tatsuo
Inazawa, Johji
Multiple Primary Cancers with Microsatellite Instability: Report of a Case
title Multiple Primary Cancers with Microsatellite Instability: Report of a Case
title_full Multiple Primary Cancers with Microsatellite Instability: Report of a Case
title_fullStr Multiple Primary Cancers with Microsatellite Instability: Report of a Case
title_full_unstemmed Multiple Primary Cancers with Microsatellite Instability: Report of a Case
title_short Multiple Primary Cancers with Microsatellite Instability: Report of a Case
title_sort multiple primary cancers with microsatellite instability: report of a case
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920989/
https://www.ncbi.nlm.nih.gov/pubmed/8609041
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00207.x
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