Tumor Necrosis Factor Production and Colon Cancer

Tumor necrosis factor (TNF) production in B10 mice exhibiting H‐2 gene heterogeneity and in C3H/ He mice differing in lipopolysaccharide (LPS) responsiveness was investigated following stimulation with OK‐432. TNF‐producing capacity in these mice was H‐2‐restricted, while their LPS responsiveness was independent of the gene. TNF production in humans was found to be HLA‐B antigen‐restricted. An investigation was then made of the effect of endogenous TNF induction with OK‐432 on the survival rate of colorectal cancer patients. Patients in the TNF‐producing group showed a trend toward having a better prognosis as compared to those in the TNF‐nonproducing group. Cancer therapy formulated with consideration of host responsiveness to OK‐432 may afford greater therapeutic benefit and may prolong survival.