Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats

The effect of unilateral nephrectomy on the growth of bladder tumors was investigated in male F344 rats treated with 0.05%N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine(BBN) for 6 weeks by means of macroscopical and microscopical examinations. Unilateral nephrectomy 4 weeks after the initiation of BBN admini...

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Detalles Bibliográficos
Autores principales: Saikawa, Shigeki, Kanamaru, Hiroshi, Li, Benyi, Matsukawa, Shigeru, Okada, Kenichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921012/
https://www.ncbi.nlm.nih.gov/pubmed/9045940
http://dx.doi.org/10.1111/j.1349-7006.1996.tb03121.x
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author Saikawa, Shigeki
Kanamaru, Hiroshi
Li, Benyi
Matsukawa, Shigeru
Okada, Kenichiro
author_facet Saikawa, Shigeki
Kanamaru, Hiroshi
Li, Benyi
Matsukawa, Shigeru
Okada, Kenichiro
author_sort Saikawa, Shigeki
collection PubMed
description The effect of unilateral nephrectomy on the growth of bladder tumors was investigated in male F344 rats treated with 0.05%N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine(BBN) for 6 weeks by means of macroscopical and microscopical examinations. Unilateral nephrectomy 4 weeks after the initiation of BBN administration significantly increased both the number and the volume of visible tumors per rat as compared with the sham‐operated group. Histological examination also revealed that the numbers of papillonodular hyperplasia and cancer per basement membrane were significantly increased by unilateral nephrectomy. The results imply a growth‐enhancing effect of unilateral nephrectomy on carcinogenesis of the rat bladder.
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spelling pubmed-59210122018-05-11 Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats Saikawa, Shigeki Kanamaru, Hiroshi Li, Benyi Matsukawa, Shigeru Okada, Kenichiro Jpn J Cancer Res Article The effect of unilateral nephrectomy on the growth of bladder tumors was investigated in male F344 rats treated with 0.05%N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine(BBN) for 6 weeks by means of macroscopical and microscopical examinations. Unilateral nephrectomy 4 weeks after the initiation of BBN administration significantly increased both the number and the volume of visible tumors per rat as compared with the sham‐operated group. Histological examination also revealed that the numbers of papillonodular hyperplasia and cancer per basement membrane were significantly increased by unilateral nephrectomy. The results imply a growth‐enhancing effect of unilateral nephrectomy on carcinogenesis of the rat bladder. Blackwell Publishing Ltd 1996-11 /pmc/articles/PMC5921012/ /pubmed/9045940 http://dx.doi.org/10.1111/j.1349-7006.1996.tb03121.x Text en
spellingShingle Article
Saikawa, Shigeki
Kanamaru, Hiroshi
Li, Benyi
Matsukawa, Shigeru
Okada, Kenichiro
Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats
title Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats
title_full Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats
title_fullStr Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats
title_full_unstemmed Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats
title_short Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats
title_sort promoting effect of unilateral nephrectomy on urinary bladder carcinogenesis in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921012/
https://www.ncbi.nlm.nih.gov/pubmed/9045940
http://dx.doi.org/10.1111/j.1349-7006.1996.tb03121.x
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