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No Alteration in DNA Topoisomerase I Gene Related to CPT‐11 Resistance in Human Lung Cancer

Mutations and reduced expression of DNA topoisomerase I (topo I) gene have been shown to be important in the acquisition of resistance to camptothecin and its analogues in vitro, but their significance has not been verified in vivo. We investigated possible topo I gene mutations and topo I mRNA expr...

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Detalles Bibliográficos
Autores principales:	Ohashi, Nobuyuki, Fujiwara, Yasuhiro, Yamaoka, Naoki, Katoh, Osamu, Satow, Yukio, Yamakido, Michio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1996
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921020/ https://www.ncbi.nlm.nih.gov/pubmed/9045964 http://dx.doi.org/10.1111/j.1349-7006.1996.tb03144.x

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