Loss or Somatic Mutations of hMSH2 Occur in Hereditary Nonpolyposis Colorectal Cancers with hMSH2 Germline Mutations

Hereditary nonpolyposis colorectal cancer (HNPCC) is a major cancer susceptibility syndrome known to be caused by the inheritance of mutations in DNA mismatch repair genes, such as hMSH2, hMLH1, hPMS1 and hPMS2. To investigate the role of genetic alterations of hMSH2 in HNPCC tumorigenesis, we analy...

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Detalles Bibliográficos
Autores principales: Lu, Shi‐Long, Akiyama, Yoshimitsu, Nagasaki, Hiromi, Nomizu, Tadashi, Ikeda, Eiichi, Baba, Shozo, Ushio, Kyosuke, Iwama, Takeo, Maruyama, Kazuo, Yuasa, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921088/
https://www.ncbi.nlm.nih.gov/pubmed/8613431
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00218.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921088/
https://www.ncbi.nlm.nih.gov/pubmed/8613431
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00218.x

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