Cargando…

Loss or Somatic Mutations of hMSH2 Occur in Hereditary Nonpolyposis Colorectal Cancers with hMSH2 Germline Mutations

Hereditary nonpolyposis colorectal cancer (HNPCC) is a major cancer susceptibility syndrome known to be caused by the inheritance of mutations in DNA mismatch repair genes, such as hMSH2, hMLH1, hPMS1 and hPMS2. To investigate the role of genetic alterations of hMSH2 in HNPCC tumorigenesis, we analy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Shi‐Long, Akiyama, Yoshimitsu, Nagasaki, Hiromi, Nomizu, Tadashi, Ikeda, Eiichi, Baba, Shozo, Ushio, Kyosuke, Iwama, Takeo, Maruyama, Kazuo, Yuasa, Yasuhito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1996
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921088/ https://www.ncbi.nlm.nih.gov/pubmed/8613431 http://dx.doi.org/10.1111/j.1349-7006.1996.tb00218.x

Ejemplares similares

MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases
por: Clark, Nicole, et al.
Publicado: (2013)

Population carrier frequency of hMSH2 and hMLH1 mutations
por: Dunlop, M G, et al.
Publicado: (2000)

Prevalence of Pathological Germline Mutations of hMLH1 and hMSH2 Genes in Colorectal Cancer
por: Li, Dandan, et al.
Publicado: (2013)

A Mononucleotide Markers Panel to Identify hMLH1/hMSH2 Germline Mutations
por: Pedroni, M., et al.
Publicado: (2007)

Frameshift Mutations of the hMSH6 Gene in Human Leukemia Cell Lines
por: Hosoya, Noriko, et al.
Publicado: (1998)

DNA Damage Induced MutS Homologue hMSH4 Acetylation
por: Chu, Yen-Lin, et al.
Publicado: (2013)

hMSH2 and GTBP expression in advanced stage epithelial ovarian cancer
por: Ercoli, A, et al.
Publicado: (1999)

Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs
por: Bologna-Molina, Ronell, et al.
Publicado: (2018)

hMSH2 is the most commonly mutated MMR gene in a cohort of Greek HNPCC patients
por: Apessos, A, et al.
Publicado: (2005)

MutS homologue hMSH5: role in cisplatin-induced DNA damage response
por: Tompkins, Joshua D, et al.
Publicado: (2012)

hMSH5 Regulates NHEJ and Averts Excessive Nucleotide Alterations at Repair Joints
por: Al-Soodani, Aneesa T., et al.
Publicado: (2022)

Mutational Analysis of Mismatch Repair Genes, hMLH1 and hMSH2, in Sporadic Endometrial Carcinomas with Microsatellite Instability
por: Kobayashi, Kanji, et al.
Publicado: (1996)

MutS Homologue hMSH5: Recombinational DSB Repair and Non-Synonymous Polymorphic Variants
por: Wu, Xiling, et al.
Publicado: (2013)

Frameshift Mutations and a Length Polymorphism in the hMSH3 Gene and the Spectrum of Microsatellite Instability in Sporadic Colon Cancer
por: Orimo, Hideo, et al.
Publicado: (1999)

Novel DNA Variants and Mutation Frequencies of hMLH1 and hMSH2 Genes in Colorectal Cancer in the Northeast China Population
por: Hu, Fulan, et al.
Publicado: (2013)

A missense mutation in both hMSH2 andAPC in an Ashkenazi Jewish HNPCC kindred: implications for clinical screening
por: YUAN, ZHI QIANG, et al.
Publicado: (1999)

Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer
por: Palicio, M, et al.
Publicado: (2000)

The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor α
por: Wada-Hiraike, O, et al.
Publicado: (2005)

Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus
por: Pimenta, Flávio Juliano Garcia Santos, et al.
Publicado: (2004)

Mapping of the methylation pattern of the hMSH2 promoter in colon cancer, using bisulfite genomic sequencing
por: Zhang, Hua, et al.
Publicado: (2006)

hMSH5 is a nucleocytoplasmic shuttling protein whose stability depends on its subcellular localization
por: Lahaye, François, et al.
Publicado: (2010)

Expression of human DNA mismatch-repair protein, hMSH2, in patients with oral lichen planus
por: LI, HAO-BO, et al.
Publicado: (2015)

Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer
por: Kassem, H Sh, et al.
Publicado: (2001)

Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis
por: Sarmento, Dmitry José de Santana, et al.
Publicado: (2016)

Hypermethylation of mismatch repair gene hMSH2 associates with platinum-resistant disease in epithelial ovarian cancer
por: Tian, Hua, et al.
Publicado: (2019)

The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population
por: Christensen, Lise Lotte, et al.
Publicado: (2008)

Frequent loss of heterozygosity at the DNA mismatch-repair loci hMLH1 and hMSH3 in sporadic breast cancer
por: Benachenhou, N, et al.
Publicado: (1999)

Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.
por: Tomlinson, I. P., et al.
Publicado: (1996)

Mismatch Repair Protein hMLH1, but not hMSH2, Enhances Estrogen-Induced Apoptosis of Colon Cancer Cells
por: Jin, Peng, et al.
Publicado: (2017)

Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in Early Gastric Cancer (EGC)
por: Zhu, Xueru, et al.
Publicado: (2017)

MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair
por: Chu, Yen-Lin, et al.
Publicado: (2013)

hMSH2 coordinated with the expression of E2F1 promotes platinum response in epithelial ovarian cancer
por: Hu, Xiao-qian, et al.
Publicado: (2023)

Oxidative Stress Induces Nuclear-to-Cytosol Shift of hMSH3, a Potential Mechanism for EMAST in Colorectal Cancer Cells
por: Tseng-Rogenski, Stephanie S., et al.
Publicado: (2012)

miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2
por: Ye, Ling, et al.
Publicado: (2017)

Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells
por: Campregher, C, et al.
Publicado: (2008)

Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis
por: Bai, Haibo, et al.
Publicado: (2005)

Gly322Asp and Asn127Ser single nucleotide polymorphisms (SNPs) of hMSH2 mismatch repair gene and the risk of triple-negative breast cancer in Polish women
por: Smolarz, Beata, et al.
Publicado: (2014)

Frequent Microsatellite Instabilities and Analyses of the Related Genes in Familial Gastric Cancers
por: Akiyama, Yoshimitsu, et al.
Publicado: (1996)

Prediction of hereditary nonpolyposis colorectal cancer using mRNA MSH2 quantitative and the correlation with nonmodifiable factor
por: Tedjasaputra, Tjahjadi Robert, et al.
Publicado: (2021)

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
por: Pritchard, Colin C., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6f0if22ao84pjt1m494amftq0g