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Improvement of Intraperitoneal Chemotherapy for Rat Ovarian Cancer Using Cisplatin‐containing Microspheres

Microspheres consisting of L‐lactic acid and glycolic acid copolymer containing cisplatin (CDDP‐PLGA) were developed to improve the delivery of cisplatin. We evaluated the effects of intraperitoneal administration of cisplatin prepared as CDDP‐PLGA in rats with ovarian cancer. The toxicity, platinum...

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Detalles Bibliográficos
Autores principales: Kumagai, Seisuke, Sugiyama, Toru, Nishida, Takashi, Ushijima, Kimio, Yakushiji, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921101/
https://www.ncbi.nlm.nih.gov/pubmed/8641974
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00238.x
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author Kumagai, Seisuke
Sugiyama, Toru
Nishida, Takashi
Ushijima, Kimio
Yakushiji, Michiaki
author_facet Kumagai, Seisuke
Sugiyama, Toru
Nishida, Takashi
Ushijima, Kimio
Yakushiji, Michiaki
author_sort Kumagai, Seisuke
collection PubMed
description Microspheres consisting of L‐lactic acid and glycolic acid copolymer containing cisplatin (CDDP‐PLGA) were developed to improve the delivery of cisplatin. We evaluated the effects of intraperitoneal administration of cisplatin prepared as CDDP‐PLGA in rats with ovarian cancer. The toxicity, platinum distribution, and therapeutic effects of CDDP‐PLGA were evaluated as compared with those in the case of cisplatin aqueous solution. The LD(50) of CDDP‐PLGA was almost four‐fold higher than that of cisplatin aqueous solution. CDDP‐PLGA released cisplatin slowly and achieved a higher concentration in the peritoneal cavity and in peritoneal tumors for prolonged periods, while the tissue concentration of cisplatin was reduced elsewhere in the body, as compared with the case of cisplatin aqueous solution. The survival of rats with peritoneal carcinomatosis was increased by this delivery system relative to cisplatin aqueous solution. CDDP‐PLGA thus allows a higher dose to be given without increasing systemic toxicity, enhancing the therapeutic effect of cisplatin.
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spelling pubmed-59211012018-05-11 Improvement of Intraperitoneal Chemotherapy for Rat Ovarian Cancer Using Cisplatin‐containing Microspheres Kumagai, Seisuke Sugiyama, Toru Nishida, Takashi Ushijima, Kimio Yakushiji, Michiaki Jpn J Cancer Res Article Microspheres consisting of L‐lactic acid and glycolic acid copolymer containing cisplatin (CDDP‐PLGA) were developed to improve the delivery of cisplatin. We evaluated the effects of intraperitoneal administration of cisplatin prepared as CDDP‐PLGA in rats with ovarian cancer. The toxicity, platinum distribution, and therapeutic effects of CDDP‐PLGA were evaluated as compared with those in the case of cisplatin aqueous solution. The LD(50) of CDDP‐PLGA was almost four‐fold higher than that of cisplatin aqueous solution. CDDP‐PLGA released cisplatin slowly and achieved a higher concentration in the peritoneal cavity and in peritoneal tumors for prolonged periods, while the tissue concentration of cisplatin was reduced elsewhere in the body, as compared with the case of cisplatin aqueous solution. The survival of rats with peritoneal carcinomatosis was increased by this delivery system relative to cisplatin aqueous solution. CDDP‐PLGA thus allows a higher dose to be given without increasing systemic toxicity, enhancing the therapeutic effect of cisplatin. Blackwell Publishing Ltd 1996-04 /pmc/articles/PMC5921101/ /pubmed/8641974 http://dx.doi.org/10.1111/j.1349-7006.1996.tb00238.x Text en
spellingShingle Article
Kumagai, Seisuke
Sugiyama, Toru
Nishida, Takashi
Ushijima, Kimio
Yakushiji, Michiaki
Improvement of Intraperitoneal Chemotherapy for Rat Ovarian Cancer Using Cisplatin‐containing Microspheres
title Improvement of Intraperitoneal Chemotherapy for Rat Ovarian Cancer Using Cisplatin‐containing Microspheres
title_full Improvement of Intraperitoneal Chemotherapy for Rat Ovarian Cancer Using Cisplatin‐containing Microspheres
title_fullStr Improvement of Intraperitoneal Chemotherapy for Rat Ovarian Cancer Using Cisplatin‐containing Microspheres
title_full_unstemmed Improvement of Intraperitoneal Chemotherapy for Rat Ovarian Cancer Using Cisplatin‐containing Microspheres
title_short Improvement of Intraperitoneal Chemotherapy for Rat Ovarian Cancer Using Cisplatin‐containing Microspheres
title_sort improvement of intraperitoneal chemotherapy for rat ovarian cancer using cisplatin‐containing microspheres
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921101/
https://www.ncbi.nlm.nih.gov/pubmed/8641974
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00238.x
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