A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas

The effects of two host genes on retro virus‐induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T‐lymphoma‐bearing F2 mice, 45 had the AKR‐derived dominant allele at Tlsm‐1. The length of the lymphoma latent period was not related to ty...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamoto, Toshiyuki, Shisa, Hayase, Pataer, Abujiang, Lu, Ling‐min, Yoshida, Osamu, Yamada, Yoshihiro, Hiai, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921108/
https://www.ncbi.nlm.nih.gov/pubmed/8641972
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00236.x
Descripción
Sumario:The effects of two host genes on retro virus‐induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T‐lymphoma‐bearing F2 mice, 45 had the AKR‐derived dominant allele at Tlsm‐1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh‐derived allele at a major histocompatibility complex (MHC)‐linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh‐derived recessive gene was named lla (lymphoma latency acceleration).

Ejemplares similares