A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas

The effects of two host genes on retro virus‐induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T‐lymphoma‐bearing F2 mice, 45 had the AKR‐derived dominant allele at Tlsm‐1. The length of the lymphoma latent period was not related to ty...

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Autores principales: Kamoto, Toshiyuki, Shisa, Hayase, Pataer, Abujiang, Lu, Ling‐min, Yoshida, Osamu, Yamada, Yoshihiro, Hiai, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921108/
https://www.ncbi.nlm.nih.gov/pubmed/8641972
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00236.x
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author Kamoto, Toshiyuki
Shisa, Hayase
Pataer, Abujiang
Lu, Ling‐min
Yoshida, Osamu
Yamada, Yoshihiro
Hiai, Hiroshi
author_facet Kamoto, Toshiyuki
Shisa, Hayase
Pataer, Abujiang
Lu, Ling‐min
Yoshida, Osamu
Yamada, Yoshihiro
Hiai, Hiroshi
author_sort Kamoto, Toshiyuki
collection PubMed
description The effects of two host genes on retro virus‐induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T‐lymphoma‐bearing F2 mice, 45 had the AKR‐derived dominant allele at Tlsm‐1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh‐derived allele at a major histocompatibility complex (MHC)‐linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh‐derived recessive gene was named lla (lymphoma latency acceleration).
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spelling pubmed-59211082018-05-11 A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas Kamoto, Toshiyuki Shisa, Hayase Pataer, Abujiang Lu, Ling‐min Yoshida, Osamu Yamada, Yoshihiro Hiai, Hiroshi Jpn J Cancer Res Article The effects of two host genes on retro virus‐induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T‐lymphoma‐bearing F2 mice, 45 had the AKR‐derived dominant allele at Tlsm‐1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh‐derived allele at a major histocompatibility complex (MHC)‐linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh‐derived recessive gene was named lla (lymphoma latency acceleration). Blackwell Publishing Ltd 1996-04 /pmc/articles/PMC5921108/ /pubmed/8641972 http://dx.doi.org/10.1111/j.1349-7006.1996.tb00236.x Text en
spellingShingle Article
Kamoto, Toshiyuki
Shisa, Hayase
Pataer, Abujiang
Lu, Ling‐min
Yoshida, Osamu
Yamada, Yoshihiro
Hiai, Hiroshi
A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas
title A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas
title_full A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas
title_fullStr A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas
title_full_unstemmed A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas
title_short A Quantitative Trait Locus in Major Histocompatibility Complex Determining Latent Period of Mouse Lymphomas
title_sort quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921108/
https://www.ncbi.nlm.nih.gov/pubmed/8641972
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00236.x
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