Deletion Mapping of Chromosome 10 in Human Glioma

We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III glioma...

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Detalles Bibliográficos
Autores principales: Sonoda, Yukihiko, Murakami, Yoshinori, Tominaga, Teiji, Kayama, Takamasa, Yoshimoto, Takashi, Sekiya, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921111/
https://www.ncbi.nlm.nih.gov/pubmed/8641967
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00231.x
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author Sonoda, Yukihiko
Murakami, Yoshinori
Tominaga, Teiji
Kayama, Takamasa
Yoshimoto, Takashi
Sekiya, Takao
author_facet Sonoda, Yukihiko
Murakami, Yoshinori
Tominaga, Teiji
Kayama, Takamasa
Yoshimoto, Takashi
Sekiya, Takao
author_sort Sonoda, Yukihiko
collection PubMed
description We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types. We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.
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spelling pubmed-59211112018-05-11 Deletion Mapping of Chromosome 10 in Human Glioma Sonoda, Yukihiko Murakami, Yoshinori Tominaga, Teiji Kayama, Takamasa Yoshimoto, Takashi Sekiya, Takao Jpn J Cancer Res Article We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types. We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas. Blackwell Publishing Ltd 1996-04 /pmc/articles/PMC5921111/ /pubmed/8641967 http://dx.doi.org/10.1111/j.1349-7006.1996.tb00231.x Text en
spellingShingle Article
Sonoda, Yukihiko
Murakami, Yoshinori
Tominaga, Teiji
Kayama, Takamasa
Yoshimoto, Takashi
Sekiya, Takao
Deletion Mapping of Chromosome 10 in Human Glioma
title Deletion Mapping of Chromosome 10 in Human Glioma
title_full Deletion Mapping of Chromosome 10 in Human Glioma
title_fullStr Deletion Mapping of Chromosome 10 in Human Glioma
title_full_unstemmed Deletion Mapping of Chromosome 10 in Human Glioma
title_short Deletion Mapping of Chromosome 10 in Human Glioma
title_sort deletion mapping of chromosome 10 in human glioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921111/
https://www.ncbi.nlm.nih.gov/pubmed/8641967
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00231.x
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