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Prevention by 2‐Mercaptoethane Sulfonate and N‐Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate

Ferric nitrilotriacetate (Fe‐NTA) is a renal toxicant and carcinogen in rats and mice. We found that its administration results in formation of 4‐hydroxy‐2‐nonenal (HNE) in the renal proximal tubule cells of rats, and 8‐hydroxydeoxyguanosine (8‐OHdG) adducts in their DNA, suggesting a role for oxida...

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Detalles Bibliográficos
Autores principales:	Umemura, Takashi, Hasegawa, Ryuichi, Sai‐Kato, Kimie, Nishikawa, Akiyoshi, Furukawa, Fumio, Toyokuni, Shinya, Uchida, Koji, Inoue, Tohru, Kurokawa, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1996
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921195/ https://www.ncbi.nlm.nih.gov/pubmed/8878448 http://dx.doi.org/10.1111/j.1349-7006.1996.tb02115.x

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