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Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery
Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins. In recent years, the development of Hsp90-directed inhibitors has grown rapidly, and many of these inhibitors have entered clinical trials. In...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921262/ https://www.ncbi.nlm.nih.gov/pubmed/29699578 http://dx.doi.org/10.1186/s13045-018-0602-8 |