InsP(3)R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca(2+) elevation and TBK1 activity

BACKGROUND: Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca(2+) levels via the inositol 1,4,5-trisphosphate receptor (InsP(3)R) plays a critical role in this process. However, the molecular pathways linking the InsP(3)R-mediated increa...

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Detalles Bibliográficos
Autores principales: Yang, Long, Gu, Wenwen, Cheung, King-Ho, Yan, Lan, Tong, Benjamin Chun-Kit, Jiang, Yuanying, Yang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921305/
https://www.ncbi.nlm.nih.gov/pubmed/29703257
http://dx.doi.org/10.1186/s12915-018-0507-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921305/
https://www.ncbi.nlm.nih.gov/pubmed/29703257
http://dx.doi.org/10.1186/s12915-018-0507-6

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