Cargando…

Photodynamic Effect of Polyethylene Glycol–modified Fullerene on Tumor

Fullerene (Cm) efficiently generates singlet oxygen when irradiated with light, and thus should have a photodynamic effect on tumors, if it is accumulated in the tumor tissue. To explore tumor targeting of CU, we chemically modified the water–insoluble C(60) with polyethylene glycol (PEG), not only...

Descripción completa

Detalles Bibliográficos
Autores principales: Tabata, Yasuhiko, Murakami, Yoshiyuki, Ikada, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921311/
https://www.ncbi.nlm.nih.gov/pubmed/9439687
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00336.x
_version_ 1783317981523083264
author Tabata, Yasuhiko
Murakami, Yoshiyuki
Ikada, Yoshito
author_facet Tabata, Yasuhiko
Murakami, Yoshiyuki
Ikada, Yoshito
author_sort Tabata, Yasuhiko
collection PubMed
description Fullerene (Cm) efficiently generates singlet oxygen when irradiated with light, and thus should have a photodynamic effect on tumors, if it is accumulated in the tumor tissue. To explore tumor targeting of CU, we chemically modified the water–insoluble C(60) with polyethylene glycol (PEG), not only to make it soluble in water, but also to enlarge its molecular size. When injected intravenously into mice carrying a tumor mass in the hack sulicutis, the C(60)–PEG conjugate exhibited higher accumulation and more prolonged retention in the tumor tissue than in normal tissue. The conjugate was excreted without being accumulated in any specific organ. Following intravenous injection of CorPEG conjugate or Photofrin® to tumor–bearing mice, coupled with exposure of the tumor site to visible light, the volume increase of the tumor mass was suppressed and the C(60) conjugate exhibited a stronger suppressive effect than Photofrin. Histological examination revealed that conjugate injection plus light irradiation strongly induced tumor necrosis without any damage to the overlying normal skin. The antitumor effect of the conjugate increased with increasing irradiation power and C(m) dose, and cures were achieved by treatment with a dose of 424 μg/kg at an irradiation power of 107 J/cm(2). These findings indicate that PEG–modified cm is a candidate agent for photodynamic tumor therapy.
format Online
Article
Text
id pubmed-5921311
institution National Center for Biotechnology Information
language English
publishDate 1997
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-59213112018-05-11 Photodynamic Effect of Polyethylene Glycol–modified Fullerene on Tumor Tabata, Yasuhiko Murakami, Yoshiyuki Ikada, Yoshito Jpn J Cancer Res Article Fullerene (Cm) efficiently generates singlet oxygen when irradiated with light, and thus should have a photodynamic effect on tumors, if it is accumulated in the tumor tissue. To explore tumor targeting of CU, we chemically modified the water–insoluble C(60) with polyethylene glycol (PEG), not only to make it soluble in water, but also to enlarge its molecular size. When injected intravenously into mice carrying a tumor mass in the hack sulicutis, the C(60)–PEG conjugate exhibited higher accumulation and more prolonged retention in the tumor tissue than in normal tissue. The conjugate was excreted without being accumulated in any specific organ. Following intravenous injection of CorPEG conjugate or Photofrin® to tumor–bearing mice, coupled with exposure of the tumor site to visible light, the volume increase of the tumor mass was suppressed and the C(60) conjugate exhibited a stronger suppressive effect than Photofrin. Histological examination revealed that conjugate injection plus light irradiation strongly induced tumor necrosis without any damage to the overlying normal skin. The antitumor effect of the conjugate increased with increasing irradiation power and C(m) dose, and cures were achieved by treatment with a dose of 424 μg/kg at an irradiation power of 107 J/cm(2). These findings indicate that PEG–modified cm is a candidate agent for photodynamic tumor therapy. Blackwell Publishing Ltd 1997-11 /pmc/articles/PMC5921311/ /pubmed/9439687 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00336.x Text en
spellingShingle Article
Tabata, Yasuhiko
Murakami, Yoshiyuki
Ikada, Yoshito
Photodynamic Effect of Polyethylene Glycol–modified Fullerene on Tumor
title Photodynamic Effect of Polyethylene Glycol–modified Fullerene on Tumor
title_full Photodynamic Effect of Polyethylene Glycol–modified Fullerene on Tumor
title_fullStr Photodynamic Effect of Polyethylene Glycol–modified Fullerene on Tumor
title_full_unstemmed Photodynamic Effect of Polyethylene Glycol–modified Fullerene on Tumor
title_short Photodynamic Effect of Polyethylene Glycol–modified Fullerene on Tumor
title_sort photodynamic effect of polyethylene glycol–modified fullerene on tumor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921311/
https://www.ncbi.nlm.nih.gov/pubmed/9439687
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00336.x
work_keys_str_mv AT tabatayasuhiko photodynamiceffectofpolyethyleneglycolmodifiedfullereneontumor
AT murakamiyoshiyuki photodynamiceffectofpolyethyleneglycolmodifiedfullereneontumor
AT ikadayoshito photodynamiceffectofpolyethyleneglycolmodifiedfullereneontumor