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Nitric Oxide Generation from Hydroxyurea via Copper‐catalyzed Peroxidation and Implications for Pharmacological Actions of Hydroxyurea

We investigated the generation of nitric oxide (NO) by H(2)O(2)dependent peroxidation of hydroxyurea in the presence of copper‐containing proteins such as Cu, Zn‐snperoxide dismutase (Cu, Zn‐SOD) or ceruloplasmin as a catalyst. In the reaction mixture of hydroxyurea, Cu, Zn‐SOD, and H(2)O(2), “NO ge...

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Detalles Bibliográficos
Autores principales:	Sato, Keizo, Akaike, Takaaki, Sawa, Tomohiro, Miyamoto, Yoichi, Suga, Moritaka, Ando, Masayuki, Maeda, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1997
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921347/ https://www.ncbi.nlm.nih.gov/pubmed/9473738 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00349.x

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