Direct Intratumoral Gene Transfer of the Herpes Simplex Virus Thymidine Kinase Gene with DNA‐liposome Complexes: Growth Inhibition of Tumors and Lack of Localization in Normal Tissues

To constitute the site‐specific expression of the herpes simplex virus thymidine‐kinase (HSV‐TK) gene in tumor cells, we have assessed the promoter function of the simian virus 40 (SV40) promoter and the 5’flanking region of c‐erbB‐2 gene using a luciferase‐expressing reporter plasmid. After the tra...

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Detalles Bibliográficos
Autores principales: Takakuwa, Koicni, Fujita, Kazuyuki, Kikuchi, Akira, Sugaya, Susumu, Yahata, Tetsuro, Aida, Hiroshi, Kurabayashi, Takumi, Hasegawa, Isao, Tanaka, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921354/
https://www.ncbi.nlm.nih.gov/pubmed/9119745
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00362.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921354/
https://www.ncbi.nlm.nih.gov/pubmed/9119745
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00362.x

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