New perspectives: systems medicine in cardiovascular disease

BACKGROUND: Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance CVD risk assessment and might pave the way to tailored therapies. Within the l...

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Detalles Bibliográficos
Autores principales: Kramer, Frank, Just, Steffen, Zeller, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921396/
https://www.ncbi.nlm.nih.gov/pubmed/29699591
http://dx.doi.org/10.1186/s12918-018-0579-5
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author Kramer, Frank
Just, Steffen
Zeller, Tanja
author_facet Kramer, Frank
Just, Steffen
Zeller, Tanja
author_sort Kramer, Frank
collection PubMed
description BACKGROUND: Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance CVD risk assessment and might pave the way to tailored therapies. Within the last years, systems medicine has emerged as a novel tool to study the genetic, molecular and physiological interactions. CONCLUSION: In this review, we provide an overview of the current molecular-experimental, epidemiological and bioinformatical tools applied in systems medicine in the cardiovascular field. We will discuss the status and challenges in implementing interdisciplinary systems medicine approaches in CVD.
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spelling pubmed-59213962018-05-01 New perspectives: systems medicine in cardiovascular disease Kramer, Frank Just, Steffen Zeller, Tanja BMC Syst Biol Review BACKGROUND: Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance CVD risk assessment and might pave the way to tailored therapies. Within the last years, systems medicine has emerged as a novel tool to study the genetic, molecular and physiological interactions. CONCLUSION: In this review, we provide an overview of the current molecular-experimental, epidemiological and bioinformatical tools applied in systems medicine in the cardiovascular field. We will discuss the status and challenges in implementing interdisciplinary systems medicine approaches in CVD. BioMed Central 2018-04-25 /pmc/articles/PMC5921396/ /pubmed/29699591 http://dx.doi.org/10.1186/s12918-018-0579-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Kramer, Frank
Just, Steffen
Zeller, Tanja
New perspectives: systems medicine in cardiovascular disease
title New perspectives: systems medicine in cardiovascular disease
title_full New perspectives: systems medicine in cardiovascular disease
title_fullStr New perspectives: systems medicine in cardiovascular disease
title_full_unstemmed New perspectives: systems medicine in cardiovascular disease
title_short New perspectives: systems medicine in cardiovascular disease
title_sort new perspectives: systems medicine in cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921396/
https://www.ncbi.nlm.nih.gov/pubmed/29699591
http://dx.doi.org/10.1186/s12918-018-0579-5
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