Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrP(Sc)

Transmissible spongiform encephalopathies, also known as prion diseases, are a group of fatal neurodegenerative disorders affecting both humans and animals. The central pathogenic event in prion disease is the misfolding of normal prion protein (PrP(C)) into the pathogenic conformer, PrP(Sc), which...

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Detalles Bibliográficos
Autores principales: Wang, Fei, Wang, Xinhe, Abskharon, Romany, Ma, Jiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921397/
https://www.ncbi.nlm.nih.gov/pubmed/29699569
http://dx.doi.org/10.1186/s40478-018-0534-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921397/
https://www.ncbi.nlm.nih.gov/pubmed/29699569
http://dx.doi.org/10.1186/s40478-018-0534-0

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