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Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil
Myrtus communis (myrtle) is well known for its therapeutic effects pertaining to the major secondary metabolites including essential oils (EOs). EOs are composed of volatile compounds and simply evaporate or decompose leading to their instability. Preparation of EOs niosomal formulation may be a pro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921405/ https://www.ncbi.nlm.nih.gov/pubmed/29853934 http://dx.doi.org/10.4103/1735-5362.228955 |
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author | Raeiszadeh, Mahboobeh Pardakhty, Abbas Sharififar, Fariba Farsinejad, Alireza Mehrabani, Mehrnaz Hosseini-nave, Hossein Mehrabani, Mitra |
author_facet | Raeiszadeh, Mahboobeh Pardakhty, Abbas Sharififar, Fariba Farsinejad, Alireza Mehrabani, Mehrnaz Hosseini-nave, Hossein Mehrabani, Mitra |
author_sort | Raeiszadeh, Mahboobeh |
collection | PubMed |
description | Myrtus communis (myrtle) is well known for its therapeutic effects pertaining to the major secondary metabolites including essential oils (EOs). EOs are composed of volatile compounds and simply evaporate or decompose leading to their instability. Preparation of EOs niosomal formulation may be a promising approach to deal with these obstacles. Niosomal formulations of myrtle essential oil (nMEO) were provided using non-ionic surfactants and cholesterol (Chol). In the next steps, vesicle size, zeta potential, percentage of entrapment efficiency (EE%) and physical stability of nMEO were investigated. Finally, the effect of myrtle essential oil (MEO) and nMEO on microbial growth inhibition were assessed. Values for nMEO size and zeta potential ranged from 6.17 ± 0.32 to 7.24 ± 0.61 (μm) and -20.41 ± 0.17 to -31.75 ± 0.45 (mV), respectively. Higher degrees of EE% were obtained by F6 formulation (Span/Tween 60:Chol (50:50 molar ratio)). Moreover, niosomes have been reported to be stable at 4 °C during a three-month time period. It was revealed that nMEO F6 formulation inhibited growth of Staphylococcus aureus, Staphylococcus epidermidis, Serratia marcescens, and Bacillus subtilis at concentrations lower than that of MEO. Overall, it was found that stable multilamellar vesicles were formed in the presence of 0.5% MEO and F6 formulation. This formulation also exhibited better antibacterial activity than MEO. |
format | Online Article Text |
id | pubmed-5921405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59214052018-06-01 Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil Raeiszadeh, Mahboobeh Pardakhty, Abbas Sharififar, Fariba Farsinejad, Alireza Mehrabani, Mehrnaz Hosseini-nave, Hossein Mehrabani, Mitra Res Pharm Sci Original Article Myrtus communis (myrtle) is well known for its therapeutic effects pertaining to the major secondary metabolites including essential oils (EOs). EOs are composed of volatile compounds and simply evaporate or decompose leading to their instability. Preparation of EOs niosomal formulation may be a promising approach to deal with these obstacles. Niosomal formulations of myrtle essential oil (nMEO) were provided using non-ionic surfactants and cholesterol (Chol). In the next steps, vesicle size, zeta potential, percentage of entrapment efficiency (EE%) and physical stability of nMEO were investigated. Finally, the effect of myrtle essential oil (MEO) and nMEO on microbial growth inhibition were assessed. Values for nMEO size and zeta potential ranged from 6.17 ± 0.32 to 7.24 ± 0.61 (μm) and -20.41 ± 0.17 to -31.75 ± 0.45 (mV), respectively. Higher degrees of EE% were obtained by F6 formulation (Span/Tween 60:Chol (50:50 molar ratio)). Moreover, niosomes have been reported to be stable at 4 °C during a three-month time period. It was revealed that nMEO F6 formulation inhibited growth of Staphylococcus aureus, Staphylococcus epidermidis, Serratia marcescens, and Bacillus subtilis at concentrations lower than that of MEO. Overall, it was found that stable multilamellar vesicles were formed in the presence of 0.5% MEO and F6 formulation. This formulation also exhibited better antibacterial activity than MEO. Medknow Publications & Media Pvt Ltd 2018-06 /pmc/articles/PMC5921405/ /pubmed/29853934 http://dx.doi.org/10.4103/1735-5362.228955 Text en Copyright: © 2018 Research in Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Raeiszadeh, Mahboobeh Pardakhty, Abbas Sharififar, Fariba Farsinejad, Alireza Mehrabani, Mehrnaz Hosseini-nave, Hossein Mehrabani, Mitra Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil |
title | Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil |
title_full | Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil |
title_fullStr | Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil |
title_full_unstemmed | Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil |
title_short | Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil |
title_sort | development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921405/ https://www.ncbi.nlm.nih.gov/pubmed/29853934 http://dx.doi.org/10.4103/1735-5362.228955 |
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