Alternative Splicing of the FHIT Gene in Colorectal Cancers

In the present study, we examined the status of the FHIT gene in 112 colorectal cancer and 137 colorectal adenoma specimens. In a total of 5 specimens (4 colorectal cancers and 1 colorectal adenoma), a common smaller product was detected in addition to the normal size product. This smaller product h...

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Detalles Bibliográficos
Autores principales: Hibi, Kenji, Taguchi, Masumi, Nakamura, Hajime, Hirai, Atsushi, Fujikake, Yoshihiro, Matsui, Takanori, Kasai, Yasushi, Akiyama, Seiji, Ito, Katsuki, Takagi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921425/
https://www.ncbi.nlm.nih.gov/pubmed/9197530
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00393.x
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author Hibi, Kenji
Taguchi, Masumi
Nakamura, Hajime
Hirai, Atsushi
Fujikake, Yoshihiro
Matsui, Takanori
Kasai, Yasushi
Akiyama, Seiji
Ito, Katsuki
Takagi, Hiroshi
author_facet Hibi, Kenji
Taguchi, Masumi
Nakamura, Hajime
Hirai, Atsushi
Fujikake, Yoshihiro
Matsui, Takanori
Kasai, Yasushi
Akiyama, Seiji
Ito, Katsuki
Takagi, Hiroshi
author_sort Hibi, Kenji
collection PubMed
description In the present study, we examined the status of the FHIT gene in 112 colorectal cancer and 137 colorectal adenoma specimens. In a total of 5 specimens (4 colorectal cancers and 1 colorectal adenoma), a common smaller product was detected in addition to the normal size product. This smaller product had lost exon 4, the 5′ noncoding region of the FHIT gene, owing to alternative splicing. Moreover, all of the 5 tumors with alternative splicing were located lower on the rectum than the anterior peritoneal reflection.
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spelling pubmed-59214252018-05-11 Alternative Splicing of the FHIT Gene in Colorectal Cancers Hibi, Kenji Taguchi, Masumi Nakamura, Hajime Hirai, Atsushi Fujikake, Yoshihiro Matsui, Takanori Kasai, Yasushi Akiyama, Seiji Ito, Katsuki Takagi, Hiroshi Jpn J Cancer Res Article In the present study, we examined the status of the FHIT gene in 112 colorectal cancer and 137 colorectal adenoma specimens. In a total of 5 specimens (4 colorectal cancers and 1 colorectal adenoma), a common smaller product was detected in addition to the normal size product. This smaller product had lost exon 4, the 5′ noncoding region of the FHIT gene, owing to alternative splicing. Moreover, all of the 5 tumors with alternative splicing were located lower on the rectum than the anterior peritoneal reflection. Blackwell Publishing Ltd 1997-04 /pmc/articles/PMC5921425/ /pubmed/9197530 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00393.x Text en
spellingShingle Article
Hibi, Kenji
Taguchi, Masumi
Nakamura, Hajime
Hirai, Atsushi
Fujikake, Yoshihiro
Matsui, Takanori
Kasai, Yasushi
Akiyama, Seiji
Ito, Katsuki
Takagi, Hiroshi
Alternative Splicing of the FHIT Gene in Colorectal Cancers
title Alternative Splicing of the FHIT Gene in Colorectal Cancers
title_full Alternative Splicing of the FHIT Gene in Colorectal Cancers
title_fullStr Alternative Splicing of the FHIT Gene in Colorectal Cancers
title_full_unstemmed Alternative Splicing of the FHIT Gene in Colorectal Cancers
title_short Alternative Splicing of the FHIT Gene in Colorectal Cancers
title_sort alternative splicing of the fhit gene in colorectal cancers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921425/
https://www.ncbi.nlm.nih.gov/pubmed/9197530
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00393.x
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