MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma

The MAD (mothers against decapentaplegic)‐related genes, Smad2 (former name MA DR2 or JV18‐1) and Smad4 (former name DPC4), have been identified on chromosome 18q21.1, We analyzed 30 primary esophageal squamous cell carcinomas (ESCC) and 7 cell lines derived from ESCC for intragenic mutations and lo...

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Autores principales: Maesawa, Chihaya, Tamura, Gen, Nishizuka, Satoshi, Iwaya, Takeshi, Ogasawara, Satoshi, Ishida, Kaoru, Sakata, Ken, Sato, Nobuhiro, Ikeda, Kenichiro, Kimura, Yusuke, Saito, Kazuyoshi, Satodate, Ryoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1997
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921430/
https://www.ncbi.nlm.nih.gov/pubmed/9197523
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00386.x
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author Maesawa, Chihaya
Tamura, Gen
Nishizuka, Satoshi
Iwaya, Takeshi
Ogasawara, Satoshi
Ishida, Kaoru
Sakata, Ken
Sato, Nobuhiro
Ikeda, Kenichiro
Kimura, Yusuke
Saito, Kazuyoshi
Satodate, Ryoichi
author_facet Maesawa, Chihaya
Tamura, Gen
Nishizuka, Satoshi
Iwaya, Takeshi
Ogasawara, Satoshi
Ishida, Kaoru
Sakata, Ken
Sato, Nobuhiro
Ikeda, Kenichiro
Kimura, Yusuke
Saito, Kazuyoshi
Satodate, Ryoichi
author_sort Maesawa, Chihaya
collection PubMed
description The MAD (mothers against decapentaplegic)‐related genes, Smad2 (former name MA DR2 or JV18‐1) and Smad4 (former name DPC4), have been identified on chromosome 18q21.1, We analyzed 30 primary esophageal squamous cell carcinomas (ESCC) and 7 cell lines derived from ESCC for intragenic mutations and loss of heterozygosity (LOH) of the Smad2 and Smad4 genes. LOH was detected in 5 of 14 (35%) informative cases. However, no mutations in either gene were detected in either the primary carcinomas or the cell lines, and only a G‐to‐A base transition within the 3′‐untranslated region of the Smad4 gene was observed in a carcinoma. There were no homozygous deletions in either of the genes in the cell lines. MAD‐related genes on chromosome 18q21.1 are altered infrequently in ESCC.
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spelling pubmed-59214302018-05-11 MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma Maesawa, Chihaya Tamura, Gen Nishizuka, Satoshi Iwaya, Takeshi Ogasawara, Satoshi Ishida, Kaoru Sakata, Ken Sato, Nobuhiro Ikeda, Kenichiro Kimura, Yusuke Saito, Kazuyoshi Satodate, Ryoichi Jpn J Cancer Res Article The MAD (mothers against decapentaplegic)‐related genes, Smad2 (former name MA DR2 or JV18‐1) and Smad4 (former name DPC4), have been identified on chromosome 18q21.1, We analyzed 30 primary esophageal squamous cell carcinomas (ESCC) and 7 cell lines derived from ESCC for intragenic mutations and loss of heterozygosity (LOH) of the Smad2 and Smad4 genes. LOH was detected in 5 of 14 (35%) informative cases. However, no mutations in either gene were detected in either the primary carcinomas or the cell lines, and only a G‐to‐A base transition within the 3′‐untranslated region of the Smad4 gene was observed in a carcinoma. There were no homozygous deletions in either of the genes in the cell lines. MAD‐related genes on chromosome 18q21.1 are altered infrequently in ESCC. Blackwell Publishing Ltd 1997-04 /pmc/articles/PMC5921430/ /pubmed/9197523 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00386.x Text en
spellingShingle Article
Maesawa, Chihaya
Tamura, Gen
Nishizuka, Satoshi
Iwaya, Takeshi
Ogasawara, Satoshi
Ishida, Kaoru
Sakata, Ken
Sato, Nobuhiro
Ikeda, Kenichiro
Kimura, Yusuke
Saito, Kazuyoshi
Satodate, Ryoichi
MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma
title MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma
title_full MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma
title_fullStr MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma
title_full_unstemmed MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma
title_short MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma
title_sort mad‐related genes on 18q21.1, smad2 and smad4, are altered infrequently in esophageal squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921430/
https://www.ncbi.nlm.nih.gov/pubmed/9197523
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00386.x
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