Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study

Heating properties of magnetite cationic liposomes (MCL) were investigated in ex vivo experiments using implanted cell pellets. The cell pellets, which consisted of rat glioma T9 cells into which MCL had been incorporated in a petri dish, were implanted subcntaneously in the left femoral region of f...

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Detalles Bibliográficos
Autores principales: Yanase, Mitsugu, Shinkai, Masashige, Honda, Hiroyuki, Wakabayashi, Toshihiko, Yoshida, Jun, Kobayashi, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1997
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921484/
https://www.ncbi.nlm.nih.gov/pubmed/9310134
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00429.x
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author Yanase, Mitsugu
Shinkai, Masashige
Honda, Hiroyuki
Wakabayashi, Toshihiko
Yoshida, Jun
Kobayashi, Takeshi
author_facet Yanase, Mitsugu
Shinkai, Masashige
Honda, Hiroyuki
Wakabayashi, Toshihiko
Yoshida, Jun
Kobayashi, Takeshi
author_sort Yanase, Mitsugu
collection PubMed
description Heating properties of magnetite cationic liposomes (MCL) were investigated in ex vivo experiments using implanted cell pellets. The cell pellets, which consisted of rat glioma T9 cells into which MCL had been incorporated in a petri dish, were implanted subcntaneously in the left femoral region of female F344 rats. The rats were placed in a magnetic field generating coil and irradiated with an alternating magnetic field (384 Oe, 118 kHz) for 60 min. The cell pellets were heated to over 43°C by MCL in the magnetic field, hut other body parts of the rats were not heated. After 3 cycles of magnetic heating, all glioma cells were killed and no tumor take was observed.
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spelling pubmed-59214842018-05-11 Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study Yanase, Mitsugu Shinkai, Masashige Honda, Hiroyuki Wakabayashi, Toshihiko Yoshida, Jun Kobayashi, Takeshi Jpn J Cancer Res Rapid Communication Heating properties of magnetite cationic liposomes (MCL) were investigated in ex vivo experiments using implanted cell pellets. The cell pellets, which consisted of rat glioma T9 cells into which MCL had been incorporated in a petri dish, were implanted subcntaneously in the left femoral region of female F344 rats. The rats were placed in a magnetic field generating coil and irradiated with an alternating magnetic field (384 Oe, 118 kHz) for 60 min. The cell pellets were heated to over 43°C by MCL in the magnetic field, hut other body parts of the rats were not heated. After 3 cycles of magnetic heating, all glioma cells were killed and no tumor take was observed. Blackwell Publishing Ltd 1997-07 /pmc/articles/PMC5921484/ /pubmed/9310134 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00429.x Text en
spellingShingle Rapid Communication
Yanase, Mitsugu
Shinkai, Masashige
Honda, Hiroyuki
Wakabayashi, Toshihiko
Yoshida, Jun
Kobayashi, Takeshi
Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study
title Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study
title_full Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study
title_fullStr Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study
title_full_unstemmed Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study
title_short Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study
title_sort intracellular hyperthermia for cancer using magnetite cationic liposomes: ex vivo study
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921484/
https://www.ncbi.nlm.nih.gov/pubmed/9310134
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00429.x
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