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Antitumor Effect of DX‐8951, a Novel Camptothecin Analog, on Human Pancreatic Tumor Cells and Their CPT‐11‐resistant Variants Cultured in vitro and Xenografted into Nude Mice

DX‐8951 is a novel water‐soluble derivative of camptothecin. We evaluated the effects of DX‐8951 on the growth of several pancreatic tumor cell lines in vitro and in vivo. In vitro cytotoxic activity of DX‐8951 against SUIT‐2 and KP‐1N cells, as indicated by IC(50) value, was several times more pote...

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Detalles Bibliográficos
Autores principales:	Takiguchi, Soichi, Kumazawa, Eiji, Shimazoe, Takao, Tohgo, Akiko, Kono, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1997
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921502/ https://www.ncbi.nlm.nih.gov/pubmed/9330608 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00448.x

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