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Enhanced JBrowse plugins for epigenomics data visualization

BACKGROUND: New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications. RESULTS: We present a set of plugins for the genome browser JBrowse that are targeted for epigenomics visu...

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Detalles Bibliográficos
Autores principales: Hofmeister, Brigitte T., Schmitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921565/
https://www.ncbi.nlm.nih.gov/pubmed/29699480
http://dx.doi.org/10.1186/s12859-018-2160-z
Descripción
Sumario:BACKGROUND: New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications. RESULTS: We present a set of plugins for the genome browser JBrowse that are targeted for epigenomics visualizations. Specifically, we have focused on visualizing DNA base modifications, small non-coding RNAs, stranded read coverage, and sequence motif density. Additionally, we present several plugins for improved user experience such as configurable, high-quality screenshots. CONCLUSIONS: In visualizing epigenomics with traditional genomics data, we see these plugins improving scientific communication and leading to discoveries within the field of epigenomics. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12859-018-2160-z) contains supplementary material, which is available to authorized users.