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Enhanced JBrowse plugins for epigenomics data visualization

BACKGROUND: New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications. RESULTS: We present a set of plugins for the genome browser JBrowse that are targeted for epigenomics visu...

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Detalles Bibliográficos
Autores principales: Hofmeister, Brigitte T., Schmitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921565/
https://www.ncbi.nlm.nih.gov/pubmed/29699480
http://dx.doi.org/10.1186/s12859-018-2160-z
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author Hofmeister, Brigitte T.
Schmitz, Robert J.
author_facet Hofmeister, Brigitte T.
Schmitz, Robert J.
author_sort Hofmeister, Brigitte T.
collection PubMed
description BACKGROUND: New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications. RESULTS: We present a set of plugins for the genome browser JBrowse that are targeted for epigenomics visualizations. Specifically, we have focused on visualizing DNA base modifications, small non-coding RNAs, stranded read coverage, and sequence motif density. Additionally, we present several plugins for improved user experience such as configurable, high-quality screenshots. CONCLUSIONS: In visualizing epigenomics with traditional genomics data, we see these plugins improving scientific communication and leading to discoveries within the field of epigenomics. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12859-018-2160-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-59215652018-05-01 Enhanced JBrowse plugins for epigenomics data visualization Hofmeister, Brigitte T. Schmitz, Robert J. BMC Bioinformatics Software BACKGROUND: New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications. RESULTS: We present a set of plugins for the genome browser JBrowse that are targeted for epigenomics visualizations. Specifically, we have focused on visualizing DNA base modifications, small non-coding RNAs, stranded read coverage, and sequence motif density. Additionally, we present several plugins for improved user experience such as configurable, high-quality screenshots. CONCLUSIONS: In visualizing epigenomics with traditional genomics data, we see these plugins improving scientific communication and leading to discoveries within the field of epigenomics. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12859-018-2160-z) contains supplementary material, which is available to authorized users. BioMed Central 2018-04-25 /pmc/articles/PMC5921565/ /pubmed/29699480 http://dx.doi.org/10.1186/s12859-018-2160-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Software
Hofmeister, Brigitte T.
Schmitz, Robert J.
Enhanced JBrowse plugins for epigenomics data visualization
title Enhanced JBrowse plugins for epigenomics data visualization
title_full Enhanced JBrowse plugins for epigenomics data visualization
title_fullStr Enhanced JBrowse plugins for epigenomics data visualization
title_full_unstemmed Enhanced JBrowse plugins for epigenomics data visualization
title_short Enhanced JBrowse plugins for epigenomics data visualization
title_sort enhanced jbrowse plugins for epigenomics data visualization
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921565/
https://www.ncbi.nlm.nih.gov/pubmed/29699480
http://dx.doi.org/10.1186/s12859-018-2160-z
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