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Enhanced JBrowse plugins for epigenomics data visualization
BACKGROUND: New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications. RESULTS: We present a set of plugins for the genome browser JBrowse that are targeted for epigenomics visu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921565/ https://www.ncbi.nlm.nih.gov/pubmed/29699480 http://dx.doi.org/10.1186/s12859-018-2160-z |
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author | Hofmeister, Brigitte T. Schmitz, Robert J. |
author_facet | Hofmeister, Brigitte T. Schmitz, Robert J. |
author_sort | Hofmeister, Brigitte T. |
collection | PubMed |
description | BACKGROUND: New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications. RESULTS: We present a set of plugins for the genome browser JBrowse that are targeted for epigenomics visualizations. Specifically, we have focused on visualizing DNA base modifications, small non-coding RNAs, stranded read coverage, and sequence motif density. Additionally, we present several plugins for improved user experience such as configurable, high-quality screenshots. CONCLUSIONS: In visualizing epigenomics with traditional genomics data, we see these plugins improving scientific communication and leading to discoveries within the field of epigenomics. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12859-018-2160-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5921565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59215652018-05-01 Enhanced JBrowse plugins for epigenomics data visualization Hofmeister, Brigitte T. Schmitz, Robert J. BMC Bioinformatics Software BACKGROUND: New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications. RESULTS: We present a set of plugins for the genome browser JBrowse that are targeted for epigenomics visualizations. Specifically, we have focused on visualizing DNA base modifications, small non-coding RNAs, stranded read coverage, and sequence motif density. Additionally, we present several plugins for improved user experience such as configurable, high-quality screenshots. CONCLUSIONS: In visualizing epigenomics with traditional genomics data, we see these plugins improving scientific communication and leading to discoveries within the field of epigenomics. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12859-018-2160-z) contains supplementary material, which is available to authorized users. BioMed Central 2018-04-25 /pmc/articles/PMC5921565/ /pubmed/29699480 http://dx.doi.org/10.1186/s12859-018-2160-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Software Hofmeister, Brigitte T. Schmitz, Robert J. Enhanced JBrowse plugins for epigenomics data visualization |
title | Enhanced JBrowse plugins for epigenomics data visualization |
title_full | Enhanced JBrowse plugins for epigenomics data visualization |
title_fullStr | Enhanced JBrowse plugins for epigenomics data visualization |
title_full_unstemmed | Enhanced JBrowse plugins for epigenomics data visualization |
title_short | Enhanced JBrowse plugins for epigenomics data visualization |
title_sort | enhanced jbrowse plugins for epigenomics data visualization |
topic | Software |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921565/ https://www.ncbi.nlm.nih.gov/pubmed/29699480 http://dx.doi.org/10.1186/s12859-018-2160-z |
work_keys_str_mv | AT hofmeisterbrigittet enhancedjbrowsepluginsforepigenomicsdatavisualization AT schmitzrobertj enhancedjbrowsepluginsforepigenomicsdatavisualization |