The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia

To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability, mutations in the PTEN, TGFβRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 sim...

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Detalles Bibliográficos
Autores principales: Yoshinaga, Kousuke, Sasano, Hironobu, Furukawa, Toru, Yamakawa, Hiromitsu, Yuki, Michihiro, Sato, Shinji, Yajima, Akira, Horii, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921707/
https://www.ncbi.nlm.nih.gov/pubmed/9849574
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00485.x
Descripción
Sumario:To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability, mutations in the PTEN, TGFβRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX, and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX, and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC.

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