The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia

To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability, mutations in the PTEN, TGFβRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 sim...

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Autores principales: Yoshinaga, Kousuke, Sasano, Hironobu, Furukawa, Toru, Yamakawa, Hiromitsu, Yuki, Michihiro, Sato, Shinji, Yajima, Akira, Horii, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921707/
https://www.ncbi.nlm.nih.gov/pubmed/9849574
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00485.x
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author Yoshinaga, Kousuke
Sasano, Hironobu
Furukawa, Toru
Yamakawa, Hiromitsu
Yuki, Michihiro
Sato, Shinji
Yajima, Akira
Horii, Akira
author_facet Yoshinaga, Kousuke
Sasano, Hironobu
Furukawa, Toru
Yamakawa, Hiromitsu
Yuki, Michihiro
Sato, Shinji
Yajima, Akira
Horii, Akira
author_sort Yoshinaga, Kousuke
collection PubMed
description To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability, mutations in the PTEN, TGFβRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX, and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX, and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC.
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spelling pubmed-59217072018-05-11 The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia Yoshinaga, Kousuke Sasano, Hironobu Furukawa, Toru Yamakawa, Hiromitsu Yuki, Michihiro Sato, Shinji Yajima, Akira Horii, Akira Jpn J Cancer Res Article To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability, mutations in the PTEN, TGFβRII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, and 5 simple hyperplasias) as well as 8 endometrial cancers (ECs). In the ATH cases, MSIs as well as LOHs at 10q were observed at frequencies similar to those in ECs. Mutations in PTEN, BAX, and IGFIIR were observed only in ATHs and ECs. These results suggest that (1) PTEN, BAX, and IGFIIR are already mutated in ATHs, and (2) ATH is one of the precursor lesions which could lead to EC. Blackwell Publishing Ltd 1998-10 /pmc/articles/PMC5921707/ /pubmed/9849574 http://dx.doi.org/10.1111/j.1349-7006.1998.tb00485.x Text en
spellingShingle Article
Yoshinaga, Kousuke
Sasano, Hironobu
Furukawa, Toru
Yamakawa, Hiromitsu
Yuki, Michihiro
Sato, Shinji
Yajima, Akira
Horii, Akira
The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia
title The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia
title_full The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia
title_fullStr The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia
title_full_unstemmed The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia
title_short The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia
title_sort pten, bax, and igfiir genes are mutated in endometrial atypical hyperplasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921707/
https://www.ncbi.nlm.nih.gov/pubmed/9849574
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00485.x
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