Cargando…

Generation of Metastatic Variants of Eker Renal Carcinoma Cell Lines for Experimental Investigation of Renal Cancer Metastasis

We and others have demonstrated that a mutation in Tsc2 is the rate‐limiting step for renal carcinogenesis in the Eker rat model. Although inactivation of Tsc2 results in development of renal tumors, it is not sufficient for metastatic renal cell carcinomas (RCs) in the Eker rat. To investigate the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fukuda, Tomokazu, Hirayama, Youko, Mitani, Hiroaki, Maeda, Hiroshi, Tsutsumi, Masahiro, Konishi, Yoichi, Hino, Okio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1998
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921719/ https://www.ncbi.nlm.nih.gov/pubmed/9914777 http://dx.doi.org/10.1111/j.1349-7006.1998.tb00503.x

Ejemplares similares

A Novel Renal Cell Carcinoma Susceptibility Gene Maps on Chromosome 10 in the Eker Rat
por: Hino, Okio, et al.
Publicado: (1993)

Intragenic Tsc2 Somatic Mutations as Knudson's Second Hit in Spontaneous and Chemically Induced Renal Carcinomas in the Eker Rat Model
por: Kobayashi, Toshiyuki, et al.
Publicado: (1997)

Allelic Loss at the Tuberous Sclerosis (Tsc2) Gene Locus in Spontaneous Uterine Leiomyosarcomas and Pituitary Adenomas in the Eker Rat Model
por: Kubo, Yoshiaki, et al.
Publicado: (1995)

Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation‐associated renal tumors in Eker rats
por: Inoue, Tatsuya, et al.
Publicado: (2020)

Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality
por: Shiono, Masatoshi, et al.
Publicado: (2014)

A Novel Gene “Niban” Upregulated in Renal Carcinogenesis: Cloning by the cDNA‐amplified Fragment Length Polymorphism Approach
por: Majima, Shuichi, et al.
Publicado: (2000)

Development of High‐grade Renal Cell Carcinomas in Rats Independently of Somatic Mutations in the Tsc2 and VHL Tumor Suppressor Genes
por: Toyokuni, Shinya, et al.
Publicado: (1998)

A Novel Renal Carcinoma Predisposing Gene of the Nihon Rat Maps on Chromosome 10
por: Hino, Okio, et al.
Publicado: (2001)

Increased Telomerase Activities in Human Pancreatic Duct Adenocarcinomas
por: Tsutsumi, Masahiro, et al.
Publicado: (1997)

Hematogenous Renal Cell Carcinoma Metastasis in the Postoperative Temporal Bone
por: Konishi, Masaya, et al.
Publicado: (2017)

Real-world effectiveness of nivolumab plus ipilimumab and second-line therapy in Japanese untreated patients with metastatic renal cell carcinoma: 2-year analysis from a multicenter retrospective clinical study (J-cardinal study)
por: Kojima, Takahiro, et al.
Publicado: (2022)

Cloning of the Rat Homologue of the von Hippel‐Lindau Tumor Suppressor Gene and Its Non‐somatic Mutation in Rat Renal Cell Carcinomas
por: Kikuchi, Yasushi, et al.
Publicado: (1995)

Evaluation of renal function change during first-line tyrosine kinase inhibitor therapy for metastatic renal cell carcinoma
por: Ishihara, Hiroki, et al.
Publicado: (2017)

Shortened Telomere Length in Hepatocellular Carcinomas and Corresponding Background Liver Tissues of Patients Infected with Hepatitis Virus
por: Ohashi, Kazuo, et al.
Publicado: (1996)

A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
por: Okimoto, Kazuo, et al.
Publicado: (2000)

Vitamin D3 Ameliorates DNA Damage Caused by Developmental Exposure to Endocrine Disruptors in the Uterine Myometrial Stem Cells of Eker Rats
por: Elkafas, Hoda, et al.
Publicado: (2020)

Fabrication of Ternary Nanoparticles for Catalytic Ozonation to Treat Parabens: Mechanisms, Efficiency, and Effects on Ceratophyllum demersum L. and Eker Leiomyoma Tumor-3 Cells
por: Pattanateeradetch, Apiladda, et al.
Publicado: (2022)

Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma
por: Sato, Tadashi, et al.
Publicado: (2014)

Significant response to nivolumab for metastatic chromophobe renal cell carcinoma with sarcomatoid differentiation: a case report
por: Noguchi, Go, et al.
Publicado: (2018)

Pylorus-preserving total pancreatectomy for metastatic renal cell carcinoma: a case report
por: Kitade, Hiroaki, et al.
Publicado: (2015)

Prevention by Methionine of Enhancement of Hepatocarcinogenesis by Coadministration of a Choline‐deficient L‐Amino Acid‐defined Diet and Ethionine in Rats
por: Tsujiuchi, Toshifumi, et al.
Publicado: (1995)

Induction by rapamycin and proliferation‑promoting activity of Hspb1 in a Tsc2‑deficient cell line
por: Kitano, Takayuki, et al.
Publicado: (2023)

Environmental carcinogenesis – 100th anniversary of creating cancer
por: Imai, Misa, et al.
Publicado: (2015)

Mourning Dr. Alfred G. Knudson: the two‐hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex
por: Hino, Okio, et al.
Publicado: (2017)

Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
por: Sazuka, Tomokazu, et al.
Publicado: (2021)

ERC/mesothelin is expressed in human gastric cancer tissues and cell lines
por: ITO, TOMOAKI, et al.
Publicado: (2014)

Metastatic Clear Cell Renal Cell Carcinoma Presenting with a Gingival Metastasis
por: Ali, Rusha A.E., et al.
Publicado: (2016)

Optimal first-line and second-line treatments for metastatic renal cell carcinoma: current evidence
por: Sun, Maxine, et al.
Publicado: (2014)

Oncological outcomes of a multicenter cohort treated with axitinib for metastatic renal cell carcinoma
por: Osawa, Takahiro, et al.
Publicado: (2020)

First-line axitinib therapy is less effective in metastatic renal cell carcinoma with spindle histology
por: Numakura, Kazuyuki, et al.
Publicado: (2020)

Chemopreventive Efficacy of Piroxicam Administered Alone or in Combination with Lycopene and β‐Carotene on the Development of Rat Urinary Bladder Carcinoma after A N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine Treatment
por: Okajima, Eijiro, et al.
Publicado: (1997)

A Rectal Metastasis from Renal Pelvic Cancer
por: Asayama, Naoki, et al.
Publicado: (2022)

Effect of third- and fourth-line systemic therapies for metastatic renal cell carcinoma
por: Naito, Sei, et al.
Publicado: (2019)

Current Options for Second-Line Systemic Therapy in Metastatic Renal Cell Carcinoma
por: Mitsogiannis, Iraklis C., et al.
Publicado: (2022)

Significance of timing of therapeutic line on effectiveness of nivolumab for metastatic renal cell carcinoma
por: Teishima, Jun, et al.
Publicado: (2023)

Second-Line Treatment of Metastatic Renal Cell Carcinoma in the Era of Predictive Biomarkers
por: Parosanu, Andreea Ioana, et al.
Publicado: (2023)

Elevated Expression of Interleukins in Lung Adenocarcinomas Induced by N‐Nitrosobis(2‐hydroxypropyl)amine in Rats
por: Tsujiuchi, Toshifumi, et al.
Publicado: (2000)

Mutations and Reduced Expression of the Transforming Growth Factor‐β Receptor II Gene in Rat Lung Adenocarcinomas Induced by N‐Nitrosobis‐(2‐hydroxypropyl)amine
por: Tsujiuchi, Toshifumi, et al.
Publicado: (2000)

A case of novel coronavirus disease after combination therapy with nivolumab and ipilimumab for metastatic renal cell carcinoma
por: Kijima, Yu, et al.
Publicado: (2021)

Gastric Metastasis from a Primary Renal Leiomyosarcoma
por: Yodonawa, Satoshi, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_d5lsa418nul1s1s3js5gkidhp2