Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA

Hepatitis C virus (HCV), a major causative agent of post transfusion non‐A, non‐B hepatitis (NANBH), can only infect humans and chimpanzees. We produced nine transgenic mouse lines carrying a full‐length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver‐specific...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsuda, Jun‐ichi, Suzuki, Misao, Nozaki, Chikateru, Shinya, Noriko, Tashiro, Kayo, Mizuno, Kyousuke, Uchinuno, Youichi, Yamamura, Ken‐ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921765/
https://www.ncbi.nlm.nih.gov/pubmed/9548442
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00543.x
Descripción
Sumario:Hepatitis C virus (HCV), a major causative agent of post transfusion non‐A, non‐B hepatitis (NANBH), can only infect humans and chimpanzees. We produced nine transgenic mouse lines carrying a full‐length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver‐specific expression. In one of these lines HCV mRNA and HCV core protein were detected in the liver of the transgenic mouse, although the levels of expression were very low. In addition, HCV‐related antibody was detected in the serum.

Ejemplares similares