Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA

Hepatitis C virus (HCV), a major causative agent of post transfusion non‐A, non‐B hepatitis (NANBH), can only infect humans and chimpanzees. We produced nine transgenic mouse lines carrying a full‐length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver‐specific...

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Autores principales: Matsuda, Jun‐ichi, Suzuki, Misao, Nozaki, Chikateru, Shinya, Noriko, Tashiro, Kayo, Mizuno, Kyousuke, Uchinuno, Youichi, Yamamura, Ken‐ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921765/
https://www.ncbi.nlm.nih.gov/pubmed/9548442
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00543.x
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author Matsuda, Jun‐ichi
Suzuki, Misao
Nozaki, Chikateru
Shinya, Noriko
Tashiro, Kayo
Mizuno, Kyousuke
Uchinuno, Youichi
Yamamura, Ken‐ichi
author_facet Matsuda, Jun‐ichi
Suzuki, Misao
Nozaki, Chikateru
Shinya, Noriko
Tashiro, Kayo
Mizuno, Kyousuke
Uchinuno, Youichi
Yamamura, Ken‐ichi
author_sort Matsuda, Jun‐ichi
collection PubMed
description Hepatitis C virus (HCV), a major causative agent of post transfusion non‐A, non‐B hepatitis (NANBH), can only infect humans and chimpanzees. We produced nine transgenic mouse lines carrying a full‐length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver‐specific expression. In one of these lines HCV mRNA and HCV core protein were detected in the liver of the transgenic mouse, although the levels of expression were very low. In addition, HCV‐related antibody was detected in the serum.
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spelling pubmed-59217652018-05-11 Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA Matsuda, Jun‐ichi Suzuki, Misao Nozaki, Chikateru Shinya, Noriko Tashiro, Kayo Mizuno, Kyousuke Uchinuno, Youichi Yamamura, Ken‐ichi Jpn J Cancer Res Article Hepatitis C virus (HCV), a major causative agent of post transfusion non‐A, non‐B hepatitis (NANBH), can only infect humans and chimpanzees. We produced nine transgenic mouse lines carrying a full‐length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver‐specific expression. In one of these lines HCV mRNA and HCV core protein were detected in the liver of the transgenic mouse, although the levels of expression were very low. In addition, HCV‐related antibody was detected in the serum. Blackwell Publishing Ltd 1998-02 /pmc/articles/PMC5921765/ /pubmed/9548442 http://dx.doi.org/10.1111/j.1349-7006.1998.tb00543.x Text en
spellingShingle Article
Matsuda, Jun‐ichi
Suzuki, Misao
Nozaki, Chikateru
Shinya, Noriko
Tashiro, Kayo
Mizuno, Kyousuke
Uchinuno, Youichi
Yamamura, Ken‐ichi
Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA
title Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA
title_full Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA
title_fullStr Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA
title_full_unstemmed Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA
title_short Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA
title_sort transgenic mouse expressing a full‐length hepatitis c virus cdna
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921765/
https://www.ncbi.nlm.nih.gov/pubmed/9548442
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00543.x
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