Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence i...

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Detalles Bibliográficos
Autores principales: Takegawa, Kiyoshi, Mitsumori, Kunitoshi, Onodera, Hiroshi, Yasuhara, Kazuo, Kitaura, Keisuke, Shimo, Takeo, Takahashi, Michihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921766/
https://www.ncbi.nlm.nih.gov/pubmed/9548435
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00536.x
Descripción
Sumario:In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high‐dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non‐genotoxic, proliferation‐dependent mechanism.

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