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Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence i...

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Autores principales: Takegawa, Kiyoshi, Mitsumori, Kunitoshi, Onodera, Hiroshi, Yasuhara, Kazuo, Kitaura, Keisuke, Shimo, Takeo, Takahashi, Michihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921766/
https://www.ncbi.nlm.nih.gov/pubmed/9548435
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00536.x
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author Takegawa, Kiyoshi
Mitsumori, Kunitoshi
Onodera, Hiroshi
Yasuhara, Kazuo
Kitaura, Keisuke
Shimo, Takeo
Takahashi, Michihito
author_facet Takegawa, Kiyoshi
Mitsumori, Kunitoshi
Onodera, Hiroshi
Yasuhara, Kazuo
Kitaura, Keisuke
Shimo, Takeo
Takahashi, Michihito
author_sort Takegawa, Kiyoshi
collection PubMed
description In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high‐dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non‐genotoxic, proliferation‐dependent mechanism.
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spelling pubmed-59217662018-05-11 Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide Takegawa, Kiyoshi Mitsumori, Kunitoshi Onodera, Hiroshi Yasuhara, Kazuo Kitaura, Keisuke Shimo, Takeo Takahashi, Michihito Jpn J Cancer Res Article In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high‐dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non‐genotoxic, proliferation‐dependent mechanism. Blackwell Publishing Ltd 1998-02 /pmc/articles/PMC5921766/ /pubmed/9548435 http://dx.doi.org/10.1111/j.1349-7006.1998.tb00536.x Text en
spellingShingle Article
Takegawa, Kiyoshi
Mitsumori, Kunitoshi
Onodera, Hiroshi
Yasuhara, Kazuo
Kitaura, Keisuke
Shimo, Takeo
Takahashi, Michihito
Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
title Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
title_full Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
title_fullStr Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
title_full_unstemmed Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
title_short Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
title_sort induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921766/
https://www.ncbi.nlm.nih.gov/pubmed/9548435
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00536.x
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