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Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921766/ https://www.ncbi.nlm.nih.gov/pubmed/9548435 http://dx.doi.org/10.1111/j.1349-7006.1998.tb00536.x |
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author | Takegawa, Kiyoshi Mitsumori, Kunitoshi Onodera, Hiroshi Yasuhara, Kazuo Kitaura, Keisuke Shimo, Takeo Takahashi, Michihito |
author_facet | Takegawa, Kiyoshi Mitsumori, Kunitoshi Onodera, Hiroshi Yasuhara, Kazuo Kitaura, Keisuke Shimo, Takeo Takahashi, Michihito |
author_sort | Takegawa, Kiyoshi |
collection | PubMed |
description | In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high‐dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non‐genotoxic, proliferation‐dependent mechanism. |
format | Online Article Text |
id | pubmed-5921766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59217662018-05-11 Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide Takegawa, Kiyoshi Mitsumori, Kunitoshi Onodera, Hiroshi Yasuhara, Kazuo Kitaura, Keisuke Shimo, Takeo Takahashi, Michihito Jpn J Cancer Res Article In a 2‐year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high‐dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non‐genotoxic, proliferation‐dependent mechanism. Blackwell Publishing Ltd 1998-02 /pmc/articles/PMC5921766/ /pubmed/9548435 http://dx.doi.org/10.1111/j.1349-7006.1998.tb00536.x Text en |
spellingShingle | Article Takegawa, Kiyoshi Mitsumori, Kunitoshi Onodera, Hiroshi Yasuhara, Kazuo Kitaura, Keisuke Shimo, Takeo Takahashi, Michihito Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide |
title | Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide |
title_full | Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide |
title_fullStr | Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide |
title_full_unstemmed | Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide |
title_short | Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide |
title_sort | induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921766/ https://www.ncbi.nlm.nih.gov/pubmed/9548435 http://dx.doi.org/10.1111/j.1349-7006.1998.tb00536.x |
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