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The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

BACKGROUND: This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. METHODS: In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 pl...

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Autores principales: Bauersfeld, Stephan P., Kessler, Christian S., Wischnewsky, Manfred, Jaensch, Annette, Steckhan, Nico, Stange, Rainer, Kunz, Barbara, Brückner, Barbara, Sehouli, Jalid, Michalsen, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921787/
https://www.ncbi.nlm.nih.gov/pubmed/29699509
http://dx.doi.org/10.1186/s12885-018-4353-2
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author Bauersfeld, Stephan P.
Kessler, Christian S.
Wischnewsky, Manfred
Jaensch, Annette
Steckhan, Nico
Stange, Rainer
Kunz, Barbara
Brückner, Barbara
Sehouli, Jalid
Michalsen, Andreas
author_facet Bauersfeld, Stephan P.
Kessler, Christian S.
Wischnewsky, Manfred
Jaensch, Annette
Steckhan, Nico
Stange, Rainer
Kunz, Barbara
Brückner, Barbara
Sehouli, Jalid
Michalsen, Andreas
author_sort Bauersfeld, Stephan P.
collection PubMed
description BACKGROUND: This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. METHODS: In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four patients were randomized to STF in the first half of chemotherapies followed by normocaloric diet (group A;n = 18) or vice versa (group B;n = 16). Fasting started 36 h before and ended 24 h after chemotherapy (60 h-fasting period). QOL was assessed by the FACIT-measurement system. RESULTS: The chemotherapy-induced reduction of QOL was less than the Minimally Important Difference (MID; FACT-G = 5) with STF but greater than the MID for non-fasted periods. The mean chemotherapy-induced deterioration of total FACIT-F was 10.4 ± 5.3 for fasted and 27.0 ± 6.3 for non-fasted cycles in group A and 14.1 ± 5.6 for non-fasted and 11.0 ± 5.6 for fasted cycles in group B. There were no serious adverse effects. CONCLUSION: STF during chemotherapy is well tolerated and appears to improve QOL and fatigue during chemotherapy. Larger studies should prove the effect of STF as an adjunct to chemotherapy. TRIAL REGISTRATION: This trial was registered at clinicaltrials.gov: NCT01954836.
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spelling pubmed-59217872018-05-01 The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study Bauersfeld, Stephan P. Kessler, Christian S. Wischnewsky, Manfred Jaensch, Annette Steckhan, Nico Stange, Rainer Kunz, Barbara Brückner, Barbara Sehouli, Jalid Michalsen, Andreas BMC Cancer Research Article BACKGROUND: This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. METHODS: In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four patients were randomized to STF in the first half of chemotherapies followed by normocaloric diet (group A;n = 18) or vice versa (group B;n = 16). Fasting started 36 h before and ended 24 h after chemotherapy (60 h-fasting period). QOL was assessed by the FACIT-measurement system. RESULTS: The chemotherapy-induced reduction of QOL was less than the Minimally Important Difference (MID; FACT-G = 5) with STF but greater than the MID for non-fasted periods. The mean chemotherapy-induced deterioration of total FACIT-F was 10.4 ± 5.3 for fasted and 27.0 ± 6.3 for non-fasted cycles in group A and 14.1 ± 5.6 for non-fasted and 11.0 ± 5.6 for fasted cycles in group B. There were no serious adverse effects. CONCLUSION: STF during chemotherapy is well tolerated and appears to improve QOL and fatigue during chemotherapy. Larger studies should prove the effect of STF as an adjunct to chemotherapy. TRIAL REGISTRATION: This trial was registered at clinicaltrials.gov: NCT01954836. BioMed Central 2018-04-27 /pmc/articles/PMC5921787/ /pubmed/29699509 http://dx.doi.org/10.1186/s12885-018-4353-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Bauersfeld, Stephan P.
Kessler, Christian S.
Wischnewsky, Manfred
Jaensch, Annette
Steckhan, Nico
Stange, Rainer
Kunz, Barbara
Brückner, Barbara
Sehouli, Jalid
Michalsen, Andreas
The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
title The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
title_full The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
title_fullStr The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
title_full_unstemmed The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
title_short The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
title_sort effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921787/
https://www.ncbi.nlm.nih.gov/pubmed/29699509
http://dx.doi.org/10.1186/s12885-018-4353-2
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