Human Tumor Growth Suppression by Apoptosis Induced with Anti‐ErbB‐2 Chimeric Monoclonal Antibody

We established an anti‐ErbB‐2 mouse‐human chimeric monoclonal antibody (MoAb), CH401, which was able to kill cancer cells overexpressing the ErbB‐2 protein in vitro. The analysis of the killing mechanism indicated that MoAb CH401 might be the first anti‐ErbB‐2 mouse‐human chimeric MoAb which can ind...

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Autores principales: Sasaki, Shigeru, Tsujisaki, Masayuki, Jinnohara, Tsuneharu, Ishida, Tadao, Sekiya, Masuo, Adachi, Masaaki, Takahashi, Shuji, Hinoda, Yuji, Imai, Kohzoh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921853/
https://www.ncbi.nlm.nih.gov/pubmed/9685861
http://dx.doi.org/10.1111/j.1349-7006.1998.tb03298.x
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author Sasaki, Shigeru
Tsujisaki, Masayuki
Jinnohara, Tsuneharu
Ishida, Tadao
Sekiya, Masuo
Adachi, Masaaki
Takahashi, Shuji
Hinoda, Yuji
Imai, Kohzoh
author_facet Sasaki, Shigeru
Tsujisaki, Masayuki
Jinnohara, Tsuneharu
Ishida, Tadao
Sekiya, Masuo
Adachi, Masaaki
Takahashi, Shuji
Hinoda, Yuji
Imai, Kohzoh
author_sort Sasaki, Shigeru
collection PubMed
description We established an anti‐ErbB‐2 mouse‐human chimeric monoclonal antibody (MoAb), CH401, which was able to kill cancer cells overexpressing the ErbB‐2 protein in vitro. The analysis of the killing mechanism indicated that MoAb CH401 might be the first anti‐ErbB‐2 mouse‐human chimeric MoAb which can induce the apoptosis of cancer cells, since morphological changes and DNA fragmentation were recognized in MoAb CH401‐treated cells. The ErbB‐2 receptor appears to have two opposing functions: acting as a receptor both for a growth factor and for an apoptotic factor. Our results indicate that MoAb CH401 treatment may prove to be very useful for cancer therapy.
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spelling pubmed-59218532018-05-11 Human Tumor Growth Suppression by Apoptosis Induced with Anti‐ErbB‐2 Chimeric Monoclonal Antibody Sasaki, Shigeru Tsujisaki, Masayuki Jinnohara, Tsuneharu Ishida, Tadao Sekiya, Masuo Adachi, Masaaki Takahashi, Shuji Hinoda, Yuji Imai, Kohzoh Jpn J Cancer Res Article We established an anti‐ErbB‐2 mouse‐human chimeric monoclonal antibody (MoAb), CH401, which was able to kill cancer cells overexpressing the ErbB‐2 protein in vitro. The analysis of the killing mechanism indicated that MoAb CH401 might be the first anti‐ErbB‐2 mouse‐human chimeric MoAb which can induce the apoptosis of cancer cells, since morphological changes and DNA fragmentation were recognized in MoAb CH401‐treated cells. The ErbB‐2 receptor appears to have two opposing functions: acting as a receptor both for a growth factor and for an apoptotic factor. Our results indicate that MoAb CH401 treatment may prove to be very useful for cancer therapy. Blackwell Publishing Ltd 1998-05 /pmc/articles/PMC5921853/ /pubmed/9685861 http://dx.doi.org/10.1111/j.1349-7006.1998.tb03298.x Text en
spellingShingle Article
Sasaki, Shigeru
Tsujisaki, Masayuki
Jinnohara, Tsuneharu
Ishida, Tadao
Sekiya, Masuo
Adachi, Masaaki
Takahashi, Shuji
Hinoda, Yuji
Imai, Kohzoh
Human Tumor Growth Suppression by Apoptosis Induced with Anti‐ErbB‐2 Chimeric Monoclonal Antibody
title Human Tumor Growth Suppression by Apoptosis Induced with Anti‐ErbB‐2 Chimeric Monoclonal Antibody
title_full Human Tumor Growth Suppression by Apoptosis Induced with Anti‐ErbB‐2 Chimeric Monoclonal Antibody
title_fullStr Human Tumor Growth Suppression by Apoptosis Induced with Anti‐ErbB‐2 Chimeric Monoclonal Antibody
title_full_unstemmed Human Tumor Growth Suppression by Apoptosis Induced with Anti‐ErbB‐2 Chimeric Monoclonal Antibody
title_short Human Tumor Growth Suppression by Apoptosis Induced with Anti‐ErbB‐2 Chimeric Monoclonal Antibody
title_sort human tumor growth suppression by apoptosis induced with anti‐erbb‐2 chimeric monoclonal antibody
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921853/
https://www.ncbi.nlm.nih.gov/pubmed/9685861
http://dx.doi.org/10.1111/j.1349-7006.1998.tb03298.x
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