Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma

When a cachexigenic subclone (clone 20) of murine colon 26 adenocarcinoma was transplanted into female BALB/c mice, hepatic NNMT activity continued to increase until death in proportion to progressive carcass weight loss, a marker of cancer cachexia. On the other hand, noncachexigenic subclone (clon...

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Autores principales: Okamura, Atsushi, Ohmura, Yoshihisa, Islam, Md. Muzharul, Tagawa, Masatoshi, Horitsu, Keisuke, Moriyama, Yoichi, Fujimura, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921875/
https://www.ncbi.nlm.nih.gov/pubmed/9703363
http://dx.doi.org/10.1111/j.1349-7006.1998.tb03267.x
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author Okamura, Atsushi
Ohmura, Yoshihisa
Islam, Md. Muzharul
Tagawa, Masatoshi
Horitsu, Keisuke
Moriyama, Yoichi
Fujimura, Shinji
author_facet Okamura, Atsushi
Ohmura, Yoshihisa
Islam, Md. Muzharul
Tagawa, Masatoshi
Horitsu, Keisuke
Moriyama, Yoichi
Fujimura, Shinji
author_sort Okamura, Atsushi
collection PubMed
description When a cachexigenic subclone (clone 20) of murine colon 26 adenocarcinoma was transplanted into female BALB/c mice, hepatic NNMT activity continued to increase until death in proportion to progressive carcass weight loss, a marker of cancer cachexia. On the other hand, noncachexigenic subclone (clone 5)‐transplanted mice showed neither increase of NNMT activity nor carcass weight loss. Among cytostatic fluorinated pyrimidines, 5′‐dFUrd could inhibit the increase of NNMT activity and prevent weight loss in mice bearing clone 20. On the other hand, 2′‐dFUrd did not show these effects. 5‐FUra and Tegafur inhibited the increase of NNMT activity at higher concentrations. These findings suggest that the levels of hepatic NNMT activity are closely associated with the degree of weight loss, and they appear to be a useful marker of cancer cachexia.
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spelling pubmed-59218752018-05-11 Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma Okamura, Atsushi Ohmura, Yoshihisa Islam, Md. Muzharul Tagawa, Masatoshi Horitsu, Keisuke Moriyama, Yoichi Fujimura, Shinji Jpn J Cancer Res Article When a cachexigenic subclone (clone 20) of murine colon 26 adenocarcinoma was transplanted into female BALB/c mice, hepatic NNMT activity continued to increase until death in proportion to progressive carcass weight loss, a marker of cancer cachexia. On the other hand, noncachexigenic subclone (clone 5)‐transplanted mice showed neither increase of NNMT activity nor carcass weight loss. Among cytostatic fluorinated pyrimidines, 5′‐dFUrd could inhibit the increase of NNMT activity and prevent weight loss in mice bearing clone 20. On the other hand, 2′‐dFUrd did not show these effects. 5‐FUra and Tegafur inhibited the increase of NNMT activity at higher concentrations. These findings suggest that the levels of hepatic NNMT activity are closely associated with the degree of weight loss, and they appear to be a useful marker of cancer cachexia. Blackwell Publishing Ltd 1998-06 /pmc/articles/PMC5921875/ /pubmed/9703363 http://dx.doi.org/10.1111/j.1349-7006.1998.tb03267.x Text en
spellingShingle Article
Okamura, Atsushi
Ohmura, Yoshihisa
Islam, Md. Muzharul
Tagawa, Masatoshi
Horitsu, Keisuke
Moriyama, Yoichi
Fujimura, Shinji
Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma
title Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma
title_full Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma
title_fullStr Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma
title_full_unstemmed Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma
title_short Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma
title_sort increased hepatic nicotinamide n‐methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921875/
https://www.ncbi.nlm.nih.gov/pubmed/9703363
http://dx.doi.org/10.1111/j.1349-7006.1998.tb03267.x
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