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Surgical Significance of Telomerase Activity in Noncancerous Liver Tissue from Patients with Hepatocellular Carcinoma
Telomerase activity has been detected in tissue from noncancerous liver of patients with chronic liver disease, but its functional significance remains to be elucidated. We therefore evaluated the telomerase activity in surgically obtained noncancerous liver tissue from 20 hepatocellular carcinoma (...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921885/ https://www.ncbi.nlm.nih.gov/pubmed/9738979 http://dx.doi.org/10.1111/j.1349-7006.1998.tb03277.x |
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author | Kanamaru, Taichi Morita, Yasushi Itoh, Takashi Yamamoto, Masahiro Kuroda, Yoshikazu Hisatomi, Hisashi |
author_facet | Kanamaru, Taichi Morita, Yasushi Itoh, Takashi Yamamoto, Masahiro Kuroda, Yoshikazu Hisatomi, Hisashi |
author_sort | Kanamaru, Taichi |
collection | PubMed |
description | Telomerase activity has been detected in tissue from noncancerous liver of patients with chronic liver disease, but its functional significance remains to be elucidated. We therefore evaluated the telomerase activity in surgically obtained noncancerous liver tissue from 20 hepatocellular carcinoma (HCC) patients. Two samples of noncancerous liver tissue were obtained from each patient: one from the parenchyma adjacent to the HCC nodules of the resected specimen; the other from the parenchyma distant from the HCC nodules of the remnant liver. Telomerase activity was assayed by a non‐radioisotope quantitative system based on “TRAP‐eze.'’Five samples from the noncancerous liver tissue adjacent to the HCC nodules (25.0%) were telomerase‐positive; all such cases showed high‐grade malignant potential, such as intrahepatic metastasis and/or portal vascular invasion and infiltration of the fibrous capsule in the corresponding HCC nodules, and telomerase positivity showed neither a relationship with the histological activity index scores nor a correlation with liver function. Interestingly, no telomerase activity was detected in any of the 20 samples obtained from the parenchyma of the remnant liver. These results indicate that telomerase in noncancerous liver tissue is associated not with the hepatic condition accompanying HCC, but with the biological characteristics of the tumor itself, and may derive from infiltrating cancer cells. Determination of telomerase status may aid in designing more effective surgical procedures. |
format | Online Article Text |
id | pubmed-5921885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59218852018-05-11 Surgical Significance of Telomerase Activity in Noncancerous Liver Tissue from Patients with Hepatocellular Carcinoma Kanamaru, Taichi Morita, Yasushi Itoh, Takashi Yamamoto, Masahiro Kuroda, Yoshikazu Hisatomi, Hisashi Jpn J Cancer Res Article Telomerase activity has been detected in tissue from noncancerous liver of patients with chronic liver disease, but its functional significance remains to be elucidated. We therefore evaluated the telomerase activity in surgically obtained noncancerous liver tissue from 20 hepatocellular carcinoma (HCC) patients. Two samples of noncancerous liver tissue were obtained from each patient: one from the parenchyma adjacent to the HCC nodules of the resected specimen; the other from the parenchyma distant from the HCC nodules of the remnant liver. Telomerase activity was assayed by a non‐radioisotope quantitative system based on “TRAP‐eze.'’Five samples from the noncancerous liver tissue adjacent to the HCC nodules (25.0%) were telomerase‐positive; all such cases showed high‐grade malignant potential, such as intrahepatic metastasis and/or portal vascular invasion and infiltration of the fibrous capsule in the corresponding HCC nodules, and telomerase positivity showed neither a relationship with the histological activity index scores nor a correlation with liver function. Interestingly, no telomerase activity was detected in any of the 20 samples obtained from the parenchyma of the remnant liver. These results indicate that telomerase in noncancerous liver tissue is associated not with the hepatic condition accompanying HCC, but with the biological characteristics of the tumor itself, and may derive from infiltrating cancer cells. Determination of telomerase status may aid in designing more effective surgical procedures. Blackwell Publishing Ltd 1998-07 /pmc/articles/PMC5921885/ /pubmed/9738979 http://dx.doi.org/10.1111/j.1349-7006.1998.tb03277.x Text en |
spellingShingle | Article Kanamaru, Taichi Morita, Yasushi Itoh, Takashi Yamamoto, Masahiro Kuroda, Yoshikazu Hisatomi, Hisashi Surgical Significance of Telomerase Activity in Noncancerous Liver Tissue from Patients with Hepatocellular Carcinoma |
title | Surgical Significance of Telomerase Activity in Noncancerous Liver Tissue from Patients with Hepatocellular Carcinoma |
title_full | Surgical Significance of Telomerase Activity in Noncancerous Liver Tissue from Patients with Hepatocellular Carcinoma |
title_fullStr | Surgical Significance of Telomerase Activity in Noncancerous Liver Tissue from Patients with Hepatocellular Carcinoma |
title_full_unstemmed | Surgical Significance of Telomerase Activity in Noncancerous Liver Tissue from Patients with Hepatocellular Carcinoma |
title_short | Surgical Significance of Telomerase Activity in Noncancerous Liver Tissue from Patients with Hepatocellular Carcinoma |
title_sort | surgical significance of telomerase activity in noncancerous liver tissue from patients with hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921885/ https://www.ncbi.nlm.nih.gov/pubmed/9738979 http://dx.doi.org/10.1111/j.1349-7006.1998.tb03277.x |
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