Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA

The 8‐hydroxydeoxyguanosine (8‐OH‐dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non‐cancer patient controls (n=15). An increased level of 8‐OH‐dG was observed in the lung cancer group, in both the adenocarcinoma and non‐adenocarcinoma...

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Detalles Bibliográficos
Autores principales: Inoue, Masaaki, Osaki, Toshihiro, Noguchi, Masayuki, Hirohashi, Setsuo, Yasumoto, Kosei, Kasai, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921888/
https://www.ncbi.nlm.nih.gov/pubmed/9738974
http://dx.doi.org/10.1111/j.1349-7006.1998.tb03272.x
Descripción
Sumario:The 8‐hydroxydeoxyguanosine (8‐OH‐dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non‐cancer patient controls (n=15). An increased level of 8‐OH‐dG was observed in the lung cancer group, in both the adenocarcinoma and non‐adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non‐cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non‐adenocarcinoma).

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