Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA

The 8‐hydroxydeoxyguanosine (8‐OH‐dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non‐cancer patient controls (n=15). An increased level of 8‐OH‐dG was observed in the lung cancer group, in both the adenocarcinoma and non‐adenocarcinoma...

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Detalles Bibliográficos
Autores principales: Inoue, Masaaki, Osaki, Toshihiro, Noguchi, Masayuki, Hirohashi, Setsuo, Yasumoto, Kosei, Kasai, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921888/
https://www.ncbi.nlm.nih.gov/pubmed/9738974
http://dx.doi.org/10.1111/j.1349-7006.1998.tb03272.x
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author Inoue, Masaaki
Osaki, Toshihiro
Noguchi, Masayuki
Hirohashi, Setsuo
Yasumoto, Kosei
Kasai, Hiroshi
author_facet Inoue, Masaaki
Osaki, Toshihiro
Noguchi, Masayuki
Hirohashi, Setsuo
Yasumoto, Kosei
Kasai, Hiroshi
author_sort Inoue, Masaaki
collection PubMed
description The 8‐hydroxydeoxyguanosine (8‐OH‐dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non‐cancer patient controls (n=15). An increased level of 8‐OH‐dG was observed in the lung cancer group, in both the adenocarcinoma and non‐adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non‐cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non‐adenocarcinoma).
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spelling pubmed-59218882018-05-11 Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA Inoue, Masaaki Osaki, Toshihiro Noguchi, Masayuki Hirohashi, Setsuo Yasumoto, Kosei Kasai, Hiroshi Jpn J Cancer Res Article The 8‐hydroxydeoxyguanosine (8‐OH‐dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non‐cancer patient controls (n=15). An increased level of 8‐OH‐dG was observed in the lung cancer group, in both the adenocarcinoma and non‐adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non‐cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non‐adenocarcinoma). Blackwell Publishing Ltd 1998-07 /pmc/articles/PMC5921888/ /pubmed/9738974 http://dx.doi.org/10.1111/j.1349-7006.1998.tb03272.x Text en
spellingShingle Article
Inoue, Masaaki
Osaki, Toshihiro
Noguchi, Masayuki
Hirohashi, Setsuo
Yasumoto, Kosei
Kasai, Hiroshi
Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA
title Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA
title_full Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA
title_fullStr Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA
title_full_unstemmed Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA
title_short Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA
title_sort lung cancer patients have increased 8‐hydroxydeoxyguanosine levels in peripheral lung tissue dna
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921888/
https://www.ncbi.nlm.nih.gov/pubmed/9738974
http://dx.doi.org/10.1111/j.1349-7006.1998.tb03272.x
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