Comprehensive analysis of telomerase inhibition by gallotannin

Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin in...

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Autores principales: Savelyev, Nikita, Baykuzina, Polina, Dokudovskaya, Svetlana, Lavrik, Olga, Rubtsova, Maria, Dontsova, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922349/
https://www.ncbi.nlm.nih.gov/pubmed/29721155
http://dx.doi.org/10.18632/oncotarget.24642
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author Savelyev, Nikita
Baykuzina, Polina
Dokudovskaya, Svetlana
Lavrik, Olga
Rubtsova, Maria
Dontsova, Olga
author_facet Savelyev, Nikita
Baykuzina, Polina
Dokudovskaya, Svetlana
Lavrik, Olga
Rubtsova, Maria
Dontsova, Olga
author_sort Savelyev, Nikita
collection PubMed
description Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin inhibits telomerase in vitro with an half maximal inhibitory concentrations value of 130 nM, but it does not affect telomerase complex assembly and component levels in vivo. The inhibitory activity of gallotannin against telomerase provides an additional explanation for the anti-cancer activities of this compound.
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spelling pubmed-59223492018-05-02 Comprehensive analysis of telomerase inhibition by gallotannin Savelyev, Nikita Baykuzina, Polina Dokudovskaya, Svetlana Lavrik, Olga Rubtsova, Maria Dontsova, Olga Oncotarget Research Paper Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin inhibits telomerase in vitro with an half maximal inhibitory concentrations value of 130 nM, but it does not affect telomerase complex assembly and component levels in vivo. The inhibitory activity of gallotannin against telomerase provides an additional explanation for the anti-cancer activities of this compound. Impact Journals LLC 2018-04-10 /pmc/articles/PMC5922349/ /pubmed/29721155 http://dx.doi.org/10.18632/oncotarget.24642 Text en Copyright: © 2018 Savelyev et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Savelyev, Nikita
Baykuzina, Polina
Dokudovskaya, Svetlana
Lavrik, Olga
Rubtsova, Maria
Dontsova, Olga
Comprehensive analysis of telomerase inhibition by gallotannin
title Comprehensive analysis of telomerase inhibition by gallotannin
title_full Comprehensive analysis of telomerase inhibition by gallotannin
title_fullStr Comprehensive analysis of telomerase inhibition by gallotannin
title_full_unstemmed Comprehensive analysis of telomerase inhibition by gallotannin
title_short Comprehensive analysis of telomerase inhibition by gallotannin
title_sort comprehensive analysis of telomerase inhibition by gallotannin
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922349/
https://www.ncbi.nlm.nih.gov/pubmed/29721155
http://dx.doi.org/10.18632/oncotarget.24642
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