Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1

The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we...

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Autores principales: Ciarlo, Laura, Vona, Rosa, Manganelli, Valeria, Gambardella, Lucrezia, Raggi, Carla, Marconi, Matteo, Malorni, Walter, Sorice, Maurizio, Garofalo, Tina, Matarrese, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922362/
https://www.ncbi.nlm.nih.gov/pubmed/29721168
http://dx.doi.org/10.18632/oncotarget.24792
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author Ciarlo, Laura
Vona, Rosa
Manganelli, Valeria
Gambardella, Lucrezia
Raggi, Carla
Marconi, Matteo
Malorni, Walter
Sorice, Maurizio
Garofalo, Tina
Matarrese, Paola
author_facet Ciarlo, Laura
Vona, Rosa
Manganelli, Valeria
Gambardella, Lucrezia
Raggi, Carla
Marconi, Matteo
Malorni, Walter
Sorice, Maurizio
Garofalo, Tina
Matarrese, Paola
author_sort Ciarlo, Laura
collection PubMed
description The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid “rafts” in mitochondrial morphogenetic changes and their homeostasis.
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spelling pubmed-59223622018-05-02 Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1 Ciarlo, Laura Vona, Rosa Manganelli, Valeria Gambardella, Lucrezia Raggi, Carla Marconi, Matteo Malorni, Walter Sorice, Maurizio Garofalo, Tina Matarrese, Paola Oncotarget Research Paper The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid “rafts” in mitochondrial morphogenetic changes and their homeostasis. Impact Journals LLC 2018-04-10 /pmc/articles/PMC5922362/ /pubmed/29721168 http://dx.doi.org/10.18632/oncotarget.24792 Text en Copyright: © 2018 Ciarlo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ciarlo, Laura
Vona, Rosa
Manganelli, Valeria
Gambardella, Lucrezia
Raggi, Carla
Marconi, Matteo
Malorni, Walter
Sorice, Maurizio
Garofalo, Tina
Matarrese, Paola
Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1
title Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1
title_full Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1
title_fullStr Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1
title_full_unstemmed Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1
title_short Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1
title_sort recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by mdivi-1
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922362/
https://www.ncbi.nlm.nih.gov/pubmed/29721168
http://dx.doi.org/10.18632/oncotarget.24792
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