The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition

Malignant tumors often display an aberrant energy metabolism that relies primarily on glycolysis to produce adenosine triphosphate (ATP) the so-called Warburg effect or aerobic glycolysis. Thus, the elucidation of this energetic alteration in malignant tumors is important in the search for more effe...

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Detalles Bibliográficos
Autores principales: Tseng, Po-Lin, Chen, Chih-Wei, Hu, Keng-Hsun, Cheng, Hung-Chi, Lin, Yuan-Ho, Tsai, Wen-Hui, Cheng, Tain-Junn, Wu, Wei-Hsuan, Yeh, Chin-Wei, Lin, Chin-Chih, Tsai, Hui-Ju, Chang, Hao-Chun, Chuang, Jiin-Haur, Shan, Yan-Shen, Chang, Wen-Tsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922369/
https://www.ncbi.nlm.nih.gov/pubmed/29721175
http://dx.doi.org/10.18632/oncotarget.24855

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