Cargando…

Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer

Heparanase, the sole heparan sulfate (HS) degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation. Heparanase accomplishes this by degrading HS and thereby facilitating cell invasion and regulating the bioavailability...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katz, Amit, Barash, Uri, Boyango, Ilanit, Feld, Sari, Zohar, Yaniv, Hammond, Edward, Ilan, Neta, Kremer, Ran, Vlodavsky, Israel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922397/ https://www.ncbi.nlm.nih.gov/pubmed/29721203 http://dx.doi.org/10.18632/oncotarget.25022

Ejemplares similares

The prognostic significance of heparanase expression in metastatic melanoma
por: Vornicova, Olga, et al.
Publicado: (2016)

Prognostic significance of heparanase expression in primary and metastatic breast carcinoma
por: Vornicova, Olga, et al.
Publicado: (2017)

New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis
por: Barash, Uri, et al.
Publicado: (2021)

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression()
por: Singh, Preeti, et al.
Publicado: (2017)

Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation
por: Kayal, Yasmin, et al.
Publicado: (2023)

Elucidating the Consequences of Heparan Sulfate Binding by Heparanase 2
por: Gross-Cohen, Miriam, et al.
Publicado: (2021)

Clinical Significance of Heparanase Splice Variant (T5) in Renal Cell Carcinoma: Evaluation by a Novel T5-Specific Monoclonal Antibody
por: Barash, Uri, et al.
Publicado: (2012)

Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage
por: Gross-Cohen, Miriam, et al.
Publicado: (2016)

Heparanase inhibitors restrain mesothelioma
por: Lapidot, Moshe, et al.
Publicado: (2018)

Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans
por: Levy-Adam, Flonia, et al.
Publicado: (2008)

Nephroprotective Effect of Heparanase in Experimental Nephrotic Syndrome
por: Assady, Suheir, et al.
Publicado: (2015)

Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo
por: de Boer, Casper, et al.
Publicado: (2022)

Forty Years of Basic and Translational Heparanase Research
por: Vlodavsky, Israel, et al.
Publicado: (2020)

Heparanase Interacts with Resistin and Augments Its Activity
por: Novick, Daniela, et al.
Publicado: (2014)

Impact of Heparanase and the Tumor Microenvironment on Cancer Metastasis and Angiogenesis: Basic Aspects and Clinical Applications
por: Vlodavsky, Israel, et al.
Publicado: (2011)

Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2019)

Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src
por: Cohen-Kaplan, Victoria, et al.
Publicado: (2020)

Heparanase Increases Podocyte Survival and Autophagic Flux after Adriamycin-Induced Injury
por: Abu-Tayeh Suleiman, Hanan, et al.
Publicado: (2022)

Expression of heparanase in soft tissue sarcomas of adults
por: Kazarin, Olga, et al.
Publicado: (2014)

Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells
por: Batool, Tahira, et al.
Publicado: (2017)

Heparanase—A single protein with multiple enzymatic and nonenzymatic functions
por: Vlodavsky, Israel, et al.
Publicado: (2023)

Heparanase Levels Are Elevated in the Urine and Plasma of Type 2 Diabetes Patients and Associate with Blood Glucose Levels
por: Shafat, Itay, et al.
Publicado: (2011)

The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target
por: Khamaysi, Iyad, et al.
Publicado: (2017)

Role of heparanase 2 (Hpa2) in gastric cancer
por: Liu, Jingjing, et al.
Publicado: (2021)

A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane
por: Margulis, Itai, et al.
Publicado: (2021)

Elevated Urine Heparanase Levels Are Associated with Proteinuria and Decreased Renal Allograft Function
por: Shafat, Itay, et al.
Publicado: (2012)

Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma
por: Shafat, Itay, et al.
Publicado: (2011)

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity
por: Baburajeev, C. P., et al.
Publicado: (2017)

Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545
por: Abassi, Zaid, et al.
Publicado: (2017)

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease
por: Zhang, Xiao, et al.
Publicado: (2021)

Heparanase Modulates Chromatin Accessibility
por: Li, Honglian, et al.
Publicado: (2023)

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases
por: Zcharia, Eyal, et al.
Publicado: (2009)

Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells
por: Maccarana, Marco, et al.
Publicado: (2022)

Role of Heparanase on Hepatic Uptake of Intestinal Derived Lipoprotein and Fatty Streak Formation in Mice
por: Planer, David, et al.
Publicado: (2011)

Heparanase expression upregulates platelet adhesion activity and thrombogenicity
por: Cui, Hao, et al.
Publicado: (2016)

Heparanase Expression Propagates Liver Damage in CCL4-Induced Mouse Model
por: Cheng, Xiaowen, et al.
Publicado: (2022)

Patient-derived xenograft (PDX) tumors increase growth rate with time
por: Pearson, Alexander T., et al.
Publicado: (2016)

Patient-derived xenograft (PDX) models, applications and challenges in cancer research
por: Abdolahi, Shahrokh, et al.
Publicado: (2022)

Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation
por: Bitan, Menachem, et al.
Publicado: (2010)

Accelerated Resolution of AA Amyloid in Heparanase Knockout Mice Is Associated with Matrix Metalloproteases
por: Wang, Bo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tgki0nfuutfcc7ngjui6c1mbpk