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Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy
BACKGROUND: Mutations in the LMNA gene are a common cause (6–8%) of dilated cardiomyopathy (DCM) leading to heart failure, a growing health care problem worldwide. The premature aging disease Hutchinson-Gilford syndrome (HGPS) is also caused by defined mutations in the LMNA gene resulting in activat...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922532/ https://www.ncbi.nlm.nih.gov/pubmed/29702688 http://dx.doi.org/10.1371/journal.pone.0196739 |