Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory

Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders. Recently we have generated Cdkl5 KO mice by targeting exon 2 on the C57BL/6N background, and demonstrated postsynaptic overaccumulation of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors i...

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Detalles Bibliográficos
Autores principales: Okuda, Kosuke, Takao, Keizo, Watanabe, Aya, Miyakawa, Tsuyoshi, Mizuguchi, Masashi, Tanaka, Teruyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922552/
https://www.ncbi.nlm.nih.gov/pubmed/29702698
http://dx.doi.org/10.1371/journal.pone.0196587

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