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Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a motor unit determines the relative susceptibility of its motoneuron in ALS, then one would expect the most vulnerable motone...

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Autores principales: Martínez-Silva, María de Lourdes, Imhoff-Manuel, Rebecca D, Sharma, Aarti, Heckman, CJ, Shneider, Neil A, Roselli, Francesco, Zytnicki, Daniel, Manuel, Marin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922970/
https://www.ncbi.nlm.nih.gov/pubmed/29580378
http://dx.doi.org/10.7554/eLife.30955
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author Martínez-Silva, María de Lourdes
Imhoff-Manuel, Rebecca D
Sharma, Aarti
Heckman, CJ
Shneider, Neil A
Roselli, Francesco
Zytnicki, Daniel
Manuel, Marin
author_facet Martínez-Silva, María de Lourdes
Imhoff-Manuel, Rebecca D
Sharma, Aarti
Heckman, CJ
Shneider, Neil A
Roselli, Francesco
Zytnicki, Daniel
Manuel, Marin
author_sort Martínez-Silva, María de Lourdes
collection PubMed
description Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a motor unit determines the relative susceptibility of its motoneuron in ALS, then one would expect the most vulnerable motoneurons to display the strongest hyperexcitability prior to their degeneration, whereas the less vulnerable should display a moderate hyperexcitability, if any. We tested this hypothesis in vivo in two unrelated ALS mouse models by correlating the electrical properties of motoneurons with their physiological types, identified based on their motor unit contractile properties. We found that, far from being hyperexcitable, the most vulnerable motoneurons become unable to fire repetitively despite the fact that their neuromuscular junctions were still functional. Disease markers confirm that this loss of function is an early sign of degeneration. Our results indicate that intrinsic hyperexcitability is unlikely to be the cause of motoneuron degeneration.
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spelling pubmed-59229702018-04-30 Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS Martínez-Silva, María de Lourdes Imhoff-Manuel, Rebecca D Sharma, Aarti Heckman, CJ Shneider, Neil A Roselli, Francesco Zytnicki, Daniel Manuel, Marin eLife Neuroscience Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a motor unit determines the relative susceptibility of its motoneuron in ALS, then one would expect the most vulnerable motoneurons to display the strongest hyperexcitability prior to their degeneration, whereas the less vulnerable should display a moderate hyperexcitability, if any. We tested this hypothesis in vivo in two unrelated ALS mouse models by correlating the electrical properties of motoneurons with their physiological types, identified based on their motor unit contractile properties. We found that, far from being hyperexcitable, the most vulnerable motoneurons become unable to fire repetitively despite the fact that their neuromuscular junctions were still functional. Disease markers confirm that this loss of function is an early sign of degeneration. Our results indicate that intrinsic hyperexcitability is unlikely to be the cause of motoneuron degeneration. eLife Sciences Publications, Ltd 2018-03-27 /pmc/articles/PMC5922970/ /pubmed/29580378 http://dx.doi.org/10.7554/eLife.30955 Text en © 2018, Martínez-Silva et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Martínez-Silva, María de Lourdes
Imhoff-Manuel, Rebecca D
Sharma, Aarti
Heckman, CJ
Shneider, Neil A
Roselli, Francesco
Zytnicki, Daniel
Manuel, Marin
Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
title Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
title_full Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
title_fullStr Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
title_full_unstemmed Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
title_short Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
title_sort hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of als
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922970/
https://www.ncbi.nlm.nih.gov/pubmed/29580378
http://dx.doi.org/10.7554/eLife.30955
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