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Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a motor unit determines the relative susceptibility of its motoneuron in ALS, then one would expect the most vulnerable motone...

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Detalles Bibliográficos
Autores principales:	Martínez-Silva, María de Lourdes, Imhoff-Manuel, Rebecca D, Sharma, Aarti, Heckman, CJ, Shneider, Neil A, Roselli, Francesco, Zytnicki, Daniel, Manuel, Marin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922970/ https://www.ncbi.nlm.nih.gov/pubmed/29580378 http://dx.doi.org/10.7554/eLife.30955

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